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mitochondrial DNA

Genetics as it applies to evolution, molecular biology, and medical aspects.

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mitochondrial DNA

Postby anjaliz » Tue Oct 23, 2012 6:47 am

Why experiments are running on mitochondrial DNA,
is there have any effect of this DNA in human body?
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Re: mitochondrial DNA

Postby jonmoulton » Tue Oct 23, 2012 3:12 pm

Yes, there is an effect of having mitochondrial DNA in your body. You survive. Without that mitochondrial chromosome the mitochondria cannot replace critical proteins within those organelles and will not continue to function. Without functional mitochondria you cannot run the Krebs cycle. You won't make it for long on fermentation alone.

As for experiments involving mitochondrial DNA, you might start here:
http://www.ncbi.nlm.nih.gov/pubmed/?ter ... chromosome
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Postby plasmodesmata11 » Wed Oct 31, 2012 3:05 am

It's also passed down maternally, so it has many uses in that aspect
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Re: mitochondrial DNA

Postby jonmoulton » Wed Oct 31, 2012 3:23 pm

Here's recent news on that topic.

http://www.economist.com/news/science-a ... ult-people

Here's the citation and link to the original paper:

Towards germline gene therapy of inherited mitochondrial diseases.

Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S.

Nature. 2012 Oct 24. doi: 10.1038/nature11647. [Epub ahead of print]

http://www.nature.com/nature/journal/va ... 11647.html
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