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what is the relationship between hemolysis & molecular weigh

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what is the relationship between hemolysis & molecular weigh

Postby Fa23 » Sat Sep 22, 2012 11:35 pm

is it true that as the lipid water partition coefficient increases, the permeability of lipid increases and the permeability of water lowers. does that mean that a substance w/ a high lipid water partition coeffecient will be able to go through the cell membrane more easily and cause hemolysis faster?
also i know that an increase in molecular weight is related to an increase in the size of the molecule and the larger the molecule the less permeable the membrane is to that molecule, so does that mean that as the molecular weight increases, the less permeable the membrane becomes and therefore it takes more time for hemolysis?
which one plays a bigger role in affecting hemolysis?

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Postby JackBean » Wed Sep 26, 2012 11:27 am

Yes, the coefficient basically tells you, how hydrophobic/hydrophillic the substance is. However, it is it too hydrophobic then it will be stucked in the membrane and not pass to the other site.

Cis or trans? That's what matters.
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