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Why do cells age?

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Why do cells age?

Postby JoGo » Tue May 15, 2012 10:45 pm

I was just wondering if someone has a legit explanation of why cells age?
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Re: Why do cells age?

Postby jonmoulton » Tue May 15, 2012 10:57 pm

"Why" is a difficult question for science to tackle. How do cells age? That question can get you loads of information. When and where do the changes associated with aging occur? Again, there is plenty of literature addressing that. What happens to cells as they age? Sure, again that is a common research topic and plenty has been done. "Why", however, is more a question for philosophers than for science -- it's not very testable (technically, hypotheses about "why" are often not falsifiable).

Try some keywords using the term "senescence" in Wikipedia, PubMed, etc. and you'll find entries into the topic of aging. Generally though they won't answer the "why" question.
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Re: Why do cells age?

Postby JoGo » Tue May 15, 2012 11:02 pm

Sorry, what I meant to ask is HOW cells age. I've read lots of articles online but none seem to give an answer that is globally excepted. I was just curious if there is a globally accepted theory?
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Postby plasmodesmata11 » Wed May 16, 2012 2:04 am

Look up telomeres!
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Re: Why do cells age?

Postby jonmoulton » Wed May 16, 2012 2:49 pm

Other useful search terms include:
free radicals
somatic mutations
lamin A, progerin

There are various factors that contribute to aging of a cell. I don't think you'll find a single switch that explains it all. An interesting topic in aging is the disease Hutchinson-Gilford progeria, which ties in with the Lamin A topic I mentioned above.
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Postby animus » Sat May 19, 2012 11:13 pm

Ooh, I can add to what plasmodesmata11 said about telomeres.

Telomeres are repeating (and I'm pretty sure, noncoding) sequences of DNA at the tips of chromosomes. As the cell repeatedly replicates itself, bits of the ends of the chromosome don't copy, so the telomere part is giving the chromosomes leeway. Eventually, the telomere shortenings accumulate and will cut into actual coding DNA, leading to signs of aging. (Though I looked it up to double-check myself, and websites said that the bits that don't copy don't cut into the coding DNA—once it reaches the coding DNA, it makes the cell stop dividing. That sounds strange; I like what I learned, better.. hah)

Wikipedia actually has a nice list of theories about aging here:
http://en.wikipedia.org/wiki/Ageing#Biological_theories
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Postby Hasansalhi » Fri Jun 22, 2012 6:16 am

As everybody said, look up for Telomeres!
Telomeres are sequences of the DNA that are added at the tips of chromosomes, and as a cell is passing through its division cycle, the DNA is replicated and the ends are shortened as a result of the END REPLICATION PROBLEM (read about this one, it will be useful to understand it). As these parts are shortened, at some point the ends will be almost near the coding DNA leading the cell to undergo apoptosis before the coding ends are cut as well!

Telomerase is an enzyme that adds telomeres to the ends of chromosomes. The problem is that telomerase exists only in the cancerous cells (and I don't actually understand why) and germ cells. Therefore, because it doesn't exist in the normal somatic cells, these cells will die at some point, and well, as you know, not all body's tissues can regenerate, and so those which die will progress to show some aging symptoms. Take a skeletal muscle tissue for example, it doesn't regenerate and as its cells die by aging, muscle weakness will result!
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Postby citroenboom » Tue Jul 17, 2012 7:29 am

And what about my precious E. coli! They do not contain telomers :)

They age because of damage by the environment, by dividing, DNA damage and that sort of things.

In Groningen University (The Netherlands) is some nice research going on about this topic (as I understood)
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Postby oncolytic » Thu Jul 19, 2012 2:47 am

Look at this article, reliability theory of aging, it seems to be a little more fundamental than just causative theories like free radicals, etc.
http://www.news-medical.net/news/2004/10/04/5271.aspx
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Re:

Postby david23 » Thu Jul 19, 2012 3:23 am

citroenboom wrote:And what about my precious E. coli! They do not contain telomers :)

They age because of damage by the environment, by dividing, DNA damage and that sort of things.

In Groningen University (The Netherlands) is some nice research going on about this topic (as I understood)



Interesting thought, many years ago there were a few experiment about the regenerative abilities of bacteria cells. Basically they intentioned through heat, chemical, radiation etc etc induced damages to a few eColi colonies. examined them, and tagged a few cells/nucleotides, and cultured them for a few gens. Result, the later bacteria went on living normally. colonies grew.
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Postby JackBean » Thu Jul 19, 2012 6:43 am

Of course. Bacteria must survive. Technically every bacteria is old few billions of years.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: Why do cells age?

Postby KileYe » Mon Aug 13, 2012 11:55 am

I contend it is the metabolism that resulted in the aging of cells
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