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what is polycombrepress region ?

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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what is polycombrepress region ?

Postby softblackstars » Thu Mar 15, 2012 7:16 am

or it is called " polycomb repressor"?
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Postby canalon » Thu Mar 15, 2012 1:22 pm

From: http://www.plosone.org/article/info:doi ... ne.0002704
We have:
Background

The Polycomb Repressive Complex 2 (PRC2) functions as a transcriptional repressor through a mechanism that involves methylation of Histone H3 at lysine 27. The PRC2 complex activity is essential for cellular proliferation, development, and cell fate decisions. PRC2 target genes include important regulators of development and proliferation as well as tumor suppressor genes. Consistent with this, the activity of several Polycomb group (PcG) proteins is deregulated in human cancer suggesting an important role for PcGs in tumor development. Whereas the downstream functions of PcGs are well characterized, the mechanisms of their recruitment to target genes and the regulation of their activity are not fully understood.

Any particular detail?
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