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pancreatic isslets transplant

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pancreatic isslets transplant

Postby iri_black » Fri Jul 29, 2005 12:24 pm

Does anyone know if there has been a succesfull pancreatic isslets transplant anywhere in the world? In my country there were 2 attempts, but, as far as i know, none of them succesfull.
What do you think about this procedure? :?
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Postby Dr.Stein » Fri Jul 29, 2005 1:46 pm

That's very hard. Pancreatic islet is an endocrine gland, it is equipped with tons of vessels. If you remove it, you break the vessels, then bleeding..., then clotting... And there is a possibility that the recipient will reject the graft... This is risky, I don't think this will work... Why don't try to transplant some acini with islets on it? It's easier I think :?
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Postby iri_black » Fri Jul 29, 2005 3:08 pm

The donor was a pacient in clinical death (spelling?)
Before the transplant, pancreatic islets are purified, then keeped under special conditions (36 C, 5% CO2), and then transplanted by injection in the port system.
The doctor that performed this transplant was expecting the insulin-producing cells to somehow "blend-in" and start doing their job. :?
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Postby Dr.Stein » Fri Jul 29, 2005 3:45 pm

Wow, that's a radical experiment. I think it would be better if the doctor grows the pancreatic beta cells in vivo prior to do that injection. It is useful to ensure whether the culture can be survive and able to secrete insulin. I am afraid during the purification there would be some broken cells and also unexpected xenobiotics interference. It would stimulate the immune system of the patient and thus the donor pancretic cells will be rejected :?
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Postby iri_black » Fri Jul 29, 2005 4:06 pm

I really think so too.
And I can't help wondering where would the pancreatic cells migrate from the port system; I'm not sure that they could find a way to the pancreas of the diebetic patient..... :?
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Postby Dr.Stein » Fri Jul 29, 2005 4:37 pm

So far, the IDDM patients must supply themselves with insulin injection every few hours. That's pity. I saw a seven-year-old boy sitting alone on the bench of the corner of the room to inject himself with insulin pack awwawawawaa :cry: I believe there will be a solution for them...

Hey, this inspired me to start trying to make a beta cells culture :wink: Wish me luck :)
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Postby Poison » Fri Jul 29, 2005 5:49 pm

Good luck!!! ;)
It matters not how strait the gate
How charged with punishment the scroll
I am the Master of my fate
I am the Captain of my soul.
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Postby Dr.Stein » Sat Jul 30, 2005 6:49 am

Thank you. I am waiting for my mice now :D
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Postby iri_black » Thu Aug 04, 2005 9:10 am

Hey, good luck. I think diabetes is a real problem so maybe something good will come out of this :)
"A positive attitude may not solve all your problems, but it will annoy enough people to make it worth the effort" - H. Albright
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Postby zantac » Thu Aug 18, 2005 6:05 pm

hey. i think the solution for treeting diabet is hiding somewhere in the immune system.As everyone knows antibodies anti-inslets β are attacking β cells. so the deal is why Ig and the rest of immune system are seeing β cells as non-self?
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Postby MrMistery » Thu Aug 18, 2005 6:15 pm

Whatever the solution, it should come soon. The problem is really agravating, at least in my country. We have a massive insulin shortage here(minister of health=just another idiot), and it is incredibly sad to see people forming lines of more than 100 to get insuline so that they will stay alive
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