Membrane proteins

[poroto]

Dear All,

I am doing some literature search, trying to find a biological system that is similar to a purely physical
system that I am working on. As a physicist, I am a bit lost in terms of the sources to consult!

I am trying to find information of a hypothetical membrane protein, basically to see if something like it
does actually exists. The protein would be a hollow capsule containing a tethered polymer chain inside,
that is released, for example to anchor to a substrate or for recognition purposes.

I would be thrilled if someone can point in me the right direction to look for it!

Best,

Poroto

[protold]

Hola, I don´t know if this could be that you search. Look in google images about protein G coupled receptors or chemokine receptors. These are transmembrane proteins with areas in both sides in that the union of ligand in the external side promotes a conformotioal change which actives the internal side. Sorry if I don´t give you more details, but i would have to refresh my concepts. Buena suerte

[JackBean]

poroto: I think you're looking rather for something like sodium channel, which has a plug closing the channel after prolonged functioning. Thus, it does actually the opposite, what you probably want, but it could work as a model for you

[olgaka]

Hi friends, I am new here. Could anyone name the methods for the location of membrane proteins and their quantitative specification?

[JackBean]

you mean probably methods for determination of protein localization, rigth? Some of them are:
imunodetection with electron microscope
activity staining with optical microscope
fluorescent protein tags
colocalization with other proteins (but that's basically the previous)