Phospholipid

[jsmith613]

a phospholipid is produced when a triglyceride reacts with a phosphate group, eliminating a fatty acid and a phosphate group replaces the fatty acids position.

If we look at this from a chemistry point of view, what would the word reaction be.
NOTE: when the phosphate group joins on, one of the atoms attached to the oxygen is removed so that the oxygen can bond to the carbon atom on the end of the gylcerol molecule.

Therefore it can't just be: Triglyceride + phosphate --> Phospholipid + fatty acid.

(I have done my best to draw what I think happens - here it is - tell me what you think

http://s359.photobucket.com/albums/oo40 ... mage-1.jpg

NOTE: the bit that says "Don't worry about this" is the bit I actually want you to worry about. I just said this so that I did not get confused with my notes - my teacher said I don't have to know this but I would like to know it to complete my understanding.

THanks

[JackBean]

I don't think this reaction takes actually place in the cell. However, you may try to find it out here
http://www.genome.jp/kegg-bin/show_pathway?map00564

Anyway, if you're interested in the reaction's name, you know what type of substance triacylglycerol is? And how is it called, if you exchange one acid with other one?

[jsmith613]

That diagram was so confusing!

The triglyceride is an ester so is the reaction substiution.

So lets say we had a triglyceride and phosphoric acid, we would get a phospholipid + ?

Or in this situation would we just get the original fatty acid

[sconov]

did your teacher really teach it?
the diagram is not interesting, how could you study from that diagram?
really messy

[JackBean]

sconov: I guess you're talking to me. No, my teacher didn't teach that. That's from KEGG database, the list of whole metabolism.

jsmith: yes, substitution, but for esters there is a special name (including *ester*;)
That depends on the concentration of phosphate. If it was only in small, catalytic amount, you would end up with free glycerol and free fatty acids. If it was kind of concentrated, you would probably get some phospholipid (but the phosphate could be bound both to C1 and C2 (and C3, but that's identical with C1;)) But nothing like that takes place in the body...

[jsmith613]

jsmith: yes, substitution, but for esters there is a special name (including *ester*;)
That depends on the concentration of phosphate. If it was only in small, catalytic amount, you would end up with free glycerol and free fatty acids. If it was kind of concentrated, you would probably get some phospholipid (but the phosphate could be bound both to C1 and C2 (and C3, but that's identical with C1;)) But nothing like that takes place in the body...

So basically I only really need to worry about ONE of the Carbon groups contianing a phosphate group (as in my diagram on photobucket - see link above).

I am a little confused by the concnetration thing. Surely we do produce phospholipids - I presume you mean we only have phosphate on one Carbon group.

(The free glycerol and fatty acid would be produced alone or not? I just can't see this happening as the glycerol is the backbone to the phospholipid!)

thanks

[JackBean]

if the phosphoric acid was only in small amount, you would end up with hydrolysis rather than reesterification

[jsmith613]

So in the body they form due to a high concentration of phospholipids?
Now, we get phospholipid + something - WE HAVE TO GET SOMETHING ELSE
So i presume this something depends on what type of phosphate group we have
If we had high conc of phosphoric acid we would get phospholipid + fatty acid, right?