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Direction of Cell division

Discussion of all aspects of cellular structure, physiology and communication.

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Direction of Cell division

Postby scorpion9 » Mon Jun 07, 2010 7:43 pm

hi

its quite a while since my last biology course and ive forgotten allot about biology.
I was wondering if someone could explain me how do cells know in what direction to divide.
e.g cell is in a 3D space which leaves it at least 3 directions to divide. is it written in DNA and if so, how does the cell know its "base" direction. Also, is it necessary for a cell to know its orientation to find its way to the final position in an organism after fetal development.
what makes it more confusing is that scientist have grown rats in space and they develop normally which eliminates gravity.

so if anyone could clarify this for me it would be nice

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Postby JackBean » Mon Jun 07, 2010 7:51 pm

it's based on intracellular commmunication between cells ;)

and the direction of cell division is given by the spindle
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Postby kolean » Tue Jun 08, 2010 1:39 pm

You could also add that centrioles begin the spindle apparatus in the cell for its orientation during cellular division. This would be the intracellular (in the cell) communication.

You then want to know about cells in development, and that would be intercellualr communication (between cells). It is basically all about turning on certain genes that produce a new protein that is secreted from the cell (as a vesicle or just exocytosed) and how the next cell interacts with that secreted protein. For example, the cell can have a receptor that binds the ligand and starts a signaling cascade thru out the cell, turning on (and off) genes, and development continues. While another cell just next to that cell, has no receptor, and will not follow that signaling cascade of its neighboring cell.

Morphogen: http://en.wikipedia.org/wiki/Morphogen
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