Login

Join for Free!
112315 members


How does your body get rid of viruses

Human Anatomy, Physiology, and Medicine. Anything human!

Moderator: BioTeam

Postby Dr.Stein » Fri Jul 15, 2005 2:32 am

Naah, our body is already equipped with physical, chemical, and biochemical barriers, also we have innate and adaptive immune system, active immunosurveillance and active imunological memory. Those defenses should work properly. And definetely APC should be treated and given much more education before viruses penetrate into our fragile cells especially the laborous lymphocytes and mess up our body :evil: Whoaa I hate viruses! Grrr :twisted: :lol:
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby victor » Sat Jul 16, 2005 12:10 pm

Umm, talking about immune system, do you know anything about NK cell? I think it's called Natural Killer cells..
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Dr.Stein » Sat Jul 16, 2005 1:22 pm

NK cells derived from lymphocyte stem cells. In their development, they lack CD3, a marker of all lymphocytes. They play a role in non-specific cytoxicity, destroying pathogen-infected cells by releasing hydrolitic enzymes, perforin and granzyme. In a standard blood smear preparation they appear just like lymphocytes. You can distinguish them from lymphocytes by applying immunohistochemistry technique using CD3 marker. NK cells will show negative result for the marker.
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia


Postby victor » Thu Jul 21, 2005 11:53 am

Um...By the way...NK cell contains much IFN-Alpha and IFN-Beta but those two are different with IFN-X that is carried by T-cell...what does it mean??
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Dr.Stein » Mon Jul 25, 2005 10:35 am

Hey, wait, NK cells produce IFN-γ instead of IFN-α and IFN-β :)

IFN-γ is produced by T cells and NK cells. It takes action in activating macrophages activation, increasing expression of MHC molecules and antigen processing compnents, switching Ig class (IgM/D to IgG), suppressing Th2 (humoral immune response)

IFN-α is produced by leucocytes. It takes action in antiviral responses, increasing MHC class I expression.

IFN-β is produced by fibroblasts. Has a similar actions to IFN-α.
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby victor » Mon Jul 25, 2005 11:32 am

I've read that also, but in the front chapter it's written "NK cell is equipped with IFN-α and IFN-β. these two IFNs are different type from IFN-γ which is produced by T-cells".
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Dr.Stein » Tue Jul 26, 2005 6:56 am

Could you tell me your reference please?

Mine is Immunobiology: the Immune System in Health and Disease, 6th, by Janeway et al.
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby victor » Wed Jul 27, 2005 11:49 am

Mine is:
Jawetz, Melnick & Adelberg's medical microbiology by Geo F.Brooks, Janet S. Butel, and Stephen A. Morse. Actually mine is the translated version by medical faculty of Airlangga University. Published my Mc Graw-Hill Inc.

For Immunology, just open chapter 8 of that book...
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Dr.Stein » Wed Jul 27, 2005 12:18 pm

Translated edition eh? :P
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby victor » Fri Jul 29, 2005 11:55 am

So?? Yeah, you know that I can't read english at all so I only have the translated edition...anything wrong??are you trying to say that the translated it wrong??
Well, today I read the 'basic immunology' and I found that you're right. NK cells produced IFN-gamma...thanks
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Dr.Stein » Fri Jul 29, 2005 1:37 pm

Sorry, I did not mean that. But sometimes it is easier to understand the English version rather than the translated edition. I experienced it myself. I have Basic Histology by Junqueira & Carneiro (Indonesian edition), it makes me frustrated, then I purchased the English version and, OMG, that's nice to read! :wink:

Also, I suggest you to dig things from the source, means that if you like to study more about Immunology, use Immunology book and not General biology or something like that. If you are interesting on it, and needs an Indonesian version, I recommend you to read Imunologi Dasar by Karnen Bharatawijaya (UI Press), get the latest edition. That'a a nice book.

I am sorry if I offended you :(
Image
User avatar
Dr.Stein
King Cobra
King Cobra
 
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia

Postby victor » Mon Aug 01, 2005 11:23 am

Dr.Stein wrote:
I recommend you to read Imunologi Dasar by Karnen Bharatawijaya (UI Press), get the latest edition. That'a a nice book.

By the way, I've just bougt it and yes, it's better that the one in my first book....and I've just known that T-cell is the most difficult thing to learn the process.... :lol:
You know, when I was in 11th grade, I thought macrophages and granulocytes are the most difficult... :lol:

Hey please give some opinion:
IFN-Gamma is used as a complement and also can be used by itself. (T/F)
Why there're sooooooooo many CD??(Cluster of.......)
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

PreviousNext

Return to Human Biology

Who is online

Users browsing this forum: No registered users and 3 guests

cron