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Why are DNA and RNA are acids?Moderator: BioTeam
5 posts • Page 1 of 1
Why are DNA and RNA are acids?Why are DNA and RNA are acids? Is that due to the phosphate group.
'Molecular biology by Phil Turner at al' states that "At neutral pH, each phosphate group has a single negative charge. This is why nucelic acids are termed acids; they are the anions of strong acids".So, what I am not clear about is why negative charge brings acidity? Please give me a detailed answer. Thanks. Sanjeeva Nemani.
Re: Why are DNA and RNA are acids?HCl, in water, is H+ and Cl-. The phosphate of a nucleic acid backbone in water, is (sugar-PO4-sugar)- and has some H+ counterion dissolved in the water. However, just as we write HCl as an uncharged molecule and call it an acid (because it dissociates in water releasing an H+), we could write that backbone phosphate moiety in its uncharged form (sugar-PO3(OH)-sugar) and call it an acid, because when the protonated molecule is dissolved in water it dissociates and releases an H+.
5 posts • Page 1 of 1
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