Chaperone proteins

[ryanbarnhill]

Can anyone tell what portion of a protein chaperones bind?

[Swede]

I think chaparons bind to hydrophobic parts of proteins, no matter the aa-sequence, folding it correctly. I'm not too sure thought.

[JackBean]

The are several types of chaperons, some can bind just short part of polypeptide (e.g. after translation or during transport through membrane) or they can bind whole protein inside (as GroEL-GroES system)

[AndrewPhD]

ive always understood it as the chaperonin create a hydrophobic area to act as a "safe-haven' for the denatured proteins to renature.

[MrMistery]

@andrew
some of them do, like the GroEL-GroES complex. But there are other kind of chaperones. Proteins like Kar2 and Hrd3 seem to be able to bind any exposed hydrophobic segments, but they are nowhere near as elaborate as Gro