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PROTEIN

Genetics as it applies to evolution, molecular biology, and medical aspects.

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PROTEIN

Postby simsall » Sat Sep 19, 2009 4:04 pm

Explain how a change in the primary sctructure of a globular protein may result in a different 3D structure?
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Postby canalon » Sat Sep 19, 2009 4:05 pm

Explain why you did not read the rules before posting your homework questions. Or the sticky thread about the same subject....
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Re: PROTEIN

Postby simsall » Sat Sep 19, 2009 4:14 pm

where's the sticky thread about this qn then?
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Postby Cat » Sat Sep 19, 2009 4:17 pm

Try to explain what would happen if part of that protein originally ....RRRRRRRRRR...... became mutated to ...LLLLLLLLLL... and you will get your answer...
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Re: PROTEIN

Postby simsall » Sat Sep 19, 2009 4:46 pm

how does it become 3D tho? that confuses me...
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Postby JackBean » Sat Sep 19, 2009 5:24 pm

imagine some fairly complicated puzzle or something and then you change one piece for another, which totally does not pass into. What will happen?
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: PROTEIN

Postby simsall » Sat Sep 19, 2009 7:24 pm

the puzzle wont fit, so.....
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Postby david23 » Sat Sep 19, 2009 7:31 pm

protein folding depends on the interaction and charges of the individual amino acids. If you change them, the overall folding will be different. Thats it
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Re: PROTEIN

Postby JackBean » Sat Sep 19, 2009 7:34 pm

simsall wrote:the puzzle wont fit, so.....


won't fit or will even collapse ;)
http://www.biolib.cz/en/main/

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Postby simsall » Sat Sep 19, 2009 8:10 pm

but i still dont get how it becomes 3D?? wont the protein just collapse?
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Re: PROTEIN

Postby david23 » Sat Sep 19, 2009 10:37 pm

no they stay folded because of the inter and intra molculecular forces.

Go and cut out a strip of paper, pour glue on it and clump it together and see if it will collapse back to a strip of paper.
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Re: PROTEIN

Postby JackBean » Sun Sep 20, 2009 9:21 am

david23 wrote:no they stay folded because of the inter and intra molculecular forces.



Don't say. So, if you change some glycine, which is inside of the protein into fenylalanine, than you will still get working 3D protein? Or if will you change some Ala in alpha-helix into proline, than you will still get protein with working 3D structure? Only this minor change may cause total disruption of the structure, because after that you won't be able to get the other interactions either.
http://www.biolib.cz/en/main/

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