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b cells and active immunity

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b cells and active immunity

Postby raneynickel » Sat Aug 08, 2009 12:53 am

I have a question about developing active immunity. Upon recognizing some antigen, B cells are stimulated to divide into either plasma cells or memory cells. My question is how Memory cells are 'chosen' for the job. I understand that they're clones by process, but is there a signal that picks specific ones for the job? Or is it just random chance that just a certain few will be left designated as memory cells?
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Postby apolll » Sun Aug 23, 2009 8:55 pm

I don't exactly know an answer to this. It's just that I remember that there isn't a decision in cell fate that early. Meaning first all naive B cells become plasma cells. Only after the inflammation most of the plasma cells die but some of the plasma cells become memory cells. At least that's what I remember from lessons... But how this decision then is made I don't know. I'd guess that plasma cells producing Antibodies with extremly strong affinity to the antigen might be selected to be memory cells. Maybe through longterm binding to APCs and simultanous licencing through T helper cells?! But it's just speculation...
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Postby david23 » Fri Sep 11, 2009 11:29 pm

there are a bunch signal molecules, interleukin and cytokines that regulate these things.
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