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Th1/Th2 shift with BCG vaccine / antibiotics

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Th1/Th2 shift with BCG vaccine / antibiotics

Postby hullcrush » Sun Nov 02, 2008 4:08 am

I realize the model of th1/th2 is not perfect.
Vaccines are said to be very strong initiators of a th2 preference that could eventually polarize into permanent dominance, there are primary sources that state this.

So how does BCG differ as it causes a th1 response (or at least IFN-y) http://www.ncbi.nlm.nih.gov/pubmed/15196240?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum This is a cursory search but general consensus is that BCG polarizes the immune system to th1. How is this possible when other bacterial vaccines shift to Th2?

Antibiotics are said to generally cause th2 dominant diseases such as asthma.
But certain antibiotics stimulate Th1 production, ifn-y etc. (macrolides from what I've read).
May this just be a modulatory shift that would cease when they are stopped?
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