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Artificial Meiosis and gamete production

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Artificial Meiosis and gamete production

Postby M0381U5 » Mon Sep 01, 2008 4:03 am

Is it possible to generate a gamete artificially from a standard cell?

I Am interested in IVF protocols and the generation of an egg from a tissue sample.
and if a meiotic haploid nucleus could be transfered to a donor egg, and then fertilized, with standard IVF procedures. or any other procedures that would result in a gamete from a specific or general tissue sample.
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Postby alextemplet » Mon Sep 01, 2008 4:43 am

http://www.biology-online.org/biology-forum/about14211.html

In the human biology forum, we discussed recent research that could make it possible to turn any cell into any other cell stem-cell style. This research is still in its early stages, but I don't see any reason why we couldn't turn, say, a skin cell into a testes or ovary cell and produce a gamete. If that isn't possible yet, it might be in the very near future.
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Postby MrMistery » Sun Sep 07, 2008 2:25 am

it might be tricky though, cause you would have to artificially induce meiosis. I don't think it can be done right now. Maybe in the future....
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Re: Artificial Meiosis and gamete production

Postby profess75 » Tue Feb 24, 2009 11:13 am

In 2004 a female mouse was born called Kaguya. Born from the genetic material of two mouse eggs, each from different female mice. As an adult Kaguya grew up healthy and even had her own brood when she mated (the conventional way) with a male mouse. Kaguya’s mouse pups were born fine and went on to have their own offspring.

Essentially, a single chromosome is not female or male it’s the combination of an XX or XY chromosome that ‘generally’2 makes offspring. So combine the X chromosome of two women and that equals a female offspring.

The special thing about Kaguya is that one of the eggs used to create her had to be immature which isn’t possible in adult humans, but scientists at Tokyo University where Kaguya was born are working to get round this.

Meanwhile in Gottingen- Germany, Newcastle and Sheffield- England, Atlanta-USA and Melbourne- Australia, research using stem cells to create sperm has been achieved.

Newcastle in particular has created stem cells from adult bone marrow and both Sheffield and Atlanta are saying they are 5-10 years from creating sperm from women’s bone marrow.
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Re: Artificial Meiosis and gamete production

Postby Sepals » Thu Feb 26, 2009 4:16 pm

profess75 wrote:In 2004 a female mouse was born called Kaguya. Born from the genetic material of two mouse eggs, each from different female mice. As an adult Kaguya grew up healthy and even had her own brood when she mated (the conventional way) with a male mouse. Kaguya’s mouse pups were born fine and went on to have their own offspring.

Essentially, a single chromosome is not female or male it’s the combination of an XX or XY chromosome that ‘generally’2 makes offspring. So combine the X chromosome of two women and that equals a female offspring.

The special thing about Kaguya is that one of the eggs used to create her had to be immature which isn’t possible in adult humans, but scientists at Tokyo University where Kaguya was born are working to get round this.
That is not possible in humans due to genetic imprinting, where certain genes (~100) are active in one parental chromosome (eg - the paternal) and inactive in the other (the maternal in this case).

It may be possible to produce artificial gametes by stem cell technology, but it looks like the research is in the infancy. Here's an article if you want to read up more about it:

http://www.sciencedirect.com/science?_o ... ff168547c6
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Re: Artificial Meiosis and gamete production

Postby lauragray123 » Mon Mar 23, 2009 4:25 pm

It is appropriate only to animals, but to humans, it isn't. Creating an offspring should comes from the natural way of mating one egg cell and one sperm cell. Humans are different from animals, that's why it isn't appropriate enough to use such method. It might be hazardous.
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