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Rna polymerase in work

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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Rna polymerase in work

Postby FREAK » Sat Jul 12, 2008 3:07 am

What makes RNA\DNA-polymerase to proceed along the DNA strand biased at one direction ?
I want to know what make them move in one direction not the other. It is also amazing that they don't leave any base untranscribed along the way.... before they move they must transcribe them...oaou what's that! It's implies they don't just move but know when to move.
What is the physics or chemistry behind this type of behaviour (!)?
In molecular biology books this types of things are discussed as they are the behaviour of these enzymes.... when they describe the mechanism of transcription they just avoid to mention ... the mechanism of the mechanism.


It may seem very trivial ... but I need the answer. Please helP!
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Postby MisterATP » Sat Jul 12, 2008 7:04 am

That's not simple question. Absolutely complete mechanisim is still not known, because it involves many things (varied bonds, ultrastructure of polymerases, thermodynamics, factors and soo onnn). I suggest you to read B.Lewin. ''Genes.VIII''.
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Re: Rna polymerase in work

Postby FREAK » Sat Jul 12, 2008 9:11 am

MisterATP wrote:That's not simple question. Absolutely complete mechanisim is still not known, because it involves many things (varied bonds, ultrastructure of polymerases, thermodynamics, factors and soo onnn). I suggest you to read B.Lewin. ''Genes.VIII''.


It is a large book ( almost 1000 pages). I will be very glad if you kindly recommend some fruitfull pages.


~AA
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Postby MisterATP » Sat Jul 12, 2008 6:45 pm

You can start with 11.1 section (transcription). But straight answer to your qestion is in 11.4 section (A model for enzyme movement is suggested by the crystal structure).
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