Join for Free!
118316 members

Krebs Cycle

Discussion of all aspects of cellular structure, physiology and communication.

Moderator: BioTeam

Postby CyLMH » Fri Feb 16, 2007 4:30 pm

Dunnt know if u r still interested in this question.
the TCA circle was proprosed by Krebs. but actually, the specific research of the mechanisms were done by other scienstists such as Maritus & Knoop who showed that citrate could be formed nonenzymatically from OAA and pyruvate with H2O2 in basic medium. it was already "common sense" to the scienstists at that time that the cirtrate->isocitrate->alpha-ketoglutarate->succinate->fumarate->malate->OAA.
But a small amount of any of the intermediate would result in increasing the total reaction significantly. So Krebs proprosed the TCA cycle by closing the rxn: pyruvate + OAA->citrate + CO2
that is what i learnt from a gentle professor from India. Guess you may find almost the same info from the text book. (any biochemistry book will give detailed info on it)
hope this will do a little for you.
Posts: 14
Joined: Tue Oct 31, 2006 4:48 pm
Location: Singapore

Postby dipjyoti » Sat Feb 17, 2007 3:36 pm

What do you exactly want to know, Krebs Cycle or any thing else? Use wikipedia or google.
Thank You.
Dip Jyoti Chakraborty
User avatar
Posts: 142
Joined: Thu Sep 21, 2006 7:04 am

Postby whirlboy » Thu Feb 22, 2007 3:52 pm

i am reading the lehninger's book of biochemistry for the detail.i think it may helpfull.
i want to know his experiment he has taken for elucidation.
Posts: 13
Joined: Thu Feb 08, 2007 10:47 am
Location: Houston


Return to Cell Biology

Who is online

Users browsing this forum: No registered users and 2 guests