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Krebs Cycle

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Postby CyLMH » Fri Feb 16, 2007 4:30 pm

Dunnt know if u r still interested in this question.
the TCA circle was proprosed by Krebs. but actually, the specific research of the mechanisms were done by other scienstists such as Maritus & Knoop who showed that citrate could be formed nonenzymatically from OAA and pyruvate with H2O2 in basic medium. it was already "common sense" to the scienstists at that time that the cirtrate->isocitrate->alpha-ketoglutarate->succinate->fumarate->malate->OAA.
But a small amount of any of the intermediate would result in increasing the total reaction significantly. So Krebs proprosed the TCA cycle by closing the rxn: pyruvate + OAA->citrate + CO2
that is what i learnt from a gentle professor from India. Guess you may find almost the same info from the text book. (any biochemistry book will give detailed info on it)
hope this will do a little for you.
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Postby dipjyoti » Sat Feb 17, 2007 3:36 pm

What do you exactly want to know, Krebs Cycle or any thing else? Use wikipedia or google.
Thank You.
Dip Jyoti Chakraborty
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Postby whirlboy » Thu Feb 22, 2007 3:52 pm

i am reading the lehninger's book of biochemistry for the detail.i think it may helpfull.
i want to know his experiment he has taken for elucidation.
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