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I need an answer please

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I need an answer please

Postby gradsky » Tue Jan 23, 2007 1:43 am

Hi ,

please i want an answer for this:

what will happen if acetylchline diffuses to the blood ?
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Postby Caspase » Tue Jan 23, 2007 1:51 am

Depends on how much.

Probably nothing.
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Postby gradsky » Tue Jan 23, 2007 2:05 am

yes, but i want to know if a large amount diffuses for example from

a neuromuscular junction in case of decreased release of

acetylcholineestrase due to a disease or somewhat ...
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Postby sachin » Tue Jan 23, 2007 6:27 am

Neurotoxic venom can do that.....

It will block transimmision....
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Postby Dr.Stein » Tue Jan 23, 2007 9:10 am

If you know its function, you will see what will happen if you have too much within your blood :)
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Postby ahm_k1 » Fri Mar 23, 2007 12:16 am

i THink it will be removed immediately as you can see the physician dont depend on it to resolve the problem of myesthenia gravis as it is removed but high dose affect another things away from rapid spontaneous contraction of the muscle fibers
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Postby Revenged » Sat Mar 24, 2007 5:47 pm

ahm_k1 wrote:i THink it will be removed immediately as you can see the physician dont depend on it to resolve the problem of myesthenia gravis as it is removed but high dose affect another things away from rapid spontaneous contraction of the muscle fibers


the treatment for myasthesia gravis is to give an cholinesterase inhibitor such as neostigme (not to give acetylcholine intravenously?!)...

it's action causes inhibition of acetylcholinesterase, which reduces the breakdown of acetylcholine... this means there is more acetylcholine in neuromuscular junctions and it removes the muscle weakness associated with myasthesia gravis...

and what you are talking about is fasciculations... but you must remember that excessive stimulation of nicotinic acetylcholine receptors causes depolarisation block... this is how muscle relaxants like suxamethonium cause paralysis...
Last edited by Revenged on Sat Mar 24, 2007 5:56 pm, edited 1 time in total.
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Postby Revenged » Sat Mar 24, 2007 5:55 pm

sachin wrote:Neurotoxic venom can do that.....

It will block transimmision....


are you talking about the competitive blocker tubocurarine?...

it was used as an arrow poison in the americas... it causes paralysis by competing with acetylcholine for nicotinic acetylcholine receptors... it is now used as a muscle relaxant during surgery...

edit: forget about that... i see that you are talking about organophosphate poisoning now [very good example!]...

organophosphate is an cholinesterase inhibitor... too much of it causes excessive activation of the parasympathetic nervous system (nausea, vomitting..etc.) and overactivation of the somatic nervous system (e.g. depolarising block - causing muscle paralysis)...

here's a good link...

http://en.wikipedia.org/wiki/Organophos ... eurotoxins
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please

Postby ahm_k1 » Sun Mar 25, 2007 10:47 pm

This is to Mr Revenge Hello ..I hope u r in the best condition ever.
:o I hoped that I havent failed to illustrate my point of view
[img] What I meant to say is that when ACh. enter to the blood stream , its estrase lysis it into its component
I know the thing that u didnt like was the mention of Mysthenia Gravis but I have mentioned it to say that ACh. as wat 1st come to mind using ACh. to solve that problem .... fail to do due to prescence of ACh.estrase .... but u didnt get me .
According to the fasculation u mentioned I know it properly sir but I am sorry again If I wasnt able to say my opinion better as I am not english fluence....
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