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p53 and skin cancer

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p53 and skin cancer

Postby ewokgod » Sun May 15, 2005 11:04 am

What is p53? and how does it work?
what is its relation to skin cancer?

can anyone please help me

thanks
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Postby Poison » Sun May 15, 2005 2:41 pm

p53 is a tumor suppressor gene, means stops cells' uncontrolled division (cancer). when it is mutated the tissue becomes cancerous. And skin cancer is one of those cancers.

I've found an abstract about this:

Article
p53 protects against skin cancer induction by UV-B radiation

Abstract:
To assess the role of the p53 tumor suppressor gene in skin carcinogenesis by UV radiation, mice constitutively lacking one or both copies of the functional p53 gene were compared to wild-type mice for their susceptibility to UV carcinogenesis. Heterozygous mice showed greatly increased susceptibility to skin cancer induction, and homozygous p53 knockout mice were even more susceptible. Accelerated tumor development in the heterozygotes was not associated with loss of the remaining wild-type allele of p53, as reported for tumors induced by other carcinogens, but in many cases was associated with UV-induced mutations in p53. Tumors arose on the ears and dorsal skin of mice of all three genotypes, and homozygous knockout mice also developed ocular tumors, mainly melanomas. Skin tumors in the p53 knockout mice were predominately squamous cell carcinomas and were associated with premalignant lesions resembling actinic keratoses, whereas those in the heterozygous and wild-type mice were mainly sarcomas. These results demonstrate the importance of p53 in protecting against UV-induced cancers, particularly in the eye and epidermis.

From:
http://www.nature.com/cgi-taf/DynaPage. ... 1116168227
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Postby MrMistery » Sun May 15, 2005 5:52 pm

Finally someone asked about cancer. happy Poison? :D :D
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Postby ewokgod » Mon May 16, 2005 12:27 pm

thanks poison... I appreciate that
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Postby Poison » Mon May 16, 2005 5:43 pm

MrMistery wrote:Finally someone asked about cancer. happy Poison? :D :D


oh yes andrew... :D:D:D

ewokgod wrote:thanks poison... I appreciate that


you're welcome :)
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thnxs

Postby cytochromeP » Tue Jun 14, 2005 3:33 am

yeah...Thnxs Poison. :)
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Postby biostudent84 » Tue Jun 14, 2005 3:46 am

MrMistery wrote:Finally someone asked about cancer. happy Poison? :D :D


Is that one of her specialties?
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Postby Poison » Tue Jun 14, 2005 4:46 pm

I can't say that I knew everything about cancer , but I like to learn about it and I'm trying to learn more. :)
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Postby b_d_41501 » Tue Jun 14, 2005 5:33 pm

Do you work in Cancer research?
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Postby Poison » Tue Jun 14, 2005 5:41 pm

I'm studying at the university. How can I work on a field like cancer? I mean it is too difficult for a student. But I must admit that I would die to work. :)
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Postby MrMistery » Tue Jun 14, 2005 7:42 pm

Die to do research on a lethal desease? The irony of it all... :wink: :D :wink: :D
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Postby Poison » Tue Jun 14, 2005 8:04 pm

MrMistery wrote:Die to do research on a lethal desease? The irony of it all... :wink: :D :wink: :D


:) You got my point. :)
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