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Oxydative Decarbocillation

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Oxydative Decarbocillation

Postby victor » Sat May 07, 2005 1:35 pm

Could you give me the name of enzymes, coenzymes and other substances that is required for doing the Oxydative Decarbocillation? Thanks anyway for your reply.//Thx. 8)
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Postby b_d_41501 » Thu Jun 02, 2005 7:33 pm

In step 3 of the Krebs Cylce, Isocitrate undergoes oxidative decarboxylation to produce a-ketoglutarate (CO2 and NADH by-products). This is catalyzed by the Isocitrate dehydrogenase enzyme.The reaction involves dehydrogenation to Oxalosuccinate, an unstable intermediate which spontaneously decarboxylates to give a-Ketoglutarate.

Then in step 4 the a-ketoglutarate undergoes oxidative decarboxylation to produce Succinyl-CoA (CoA-SH, CO2, and NADH by-products). This step is performed by a multi-enzyme complex, the a-Ketoglutarate Dehydrogenation Complex. The multi-step reaction performed by the a-Ketoglutarate Dehydration Complex is analogous to the Pyruvate Dehydrogenase Complex, i.e. an a-keto acid undergoes oxidative decarboxylation with formation of an acyl-CoA.

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Postby Waters2 » Fri Jun 03, 2005 2:56 am

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