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How does your body get rid of viruses

Human Anatomy, Physiology, and Medicine. Anything human!

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Postby Dr.Stein » Mon Aug 01, 2005 2:23 pm

Good boy! Well, yes that's one of my fav book :) From now on, listen to Dr.Stein. :lol:

I don't get the point of your first question. As I remember, IFN-γ has nothing to do with complement, I mean they don't directly interact to each other for an ction, but they cooperate to provide immunity. They are two different things. IFN-γ is a cytokine, I already told you where it comes from, it contributes only in adaptive immune response, functions to change the behavior of its target cells. While complement, a plasma protein, contributes in both innate and adaptive immune response, functions to facilitate opsonization and membran attack activity, coopertae with immunogobulin to facilitate opsonization as well...

CD or Cluster of Differentiation is a protein molecule, functions as a surface marker for lymphocytes.You don't have to remember all the CDs, cytokines, and all things in the list. You will automatically remember them when you often use them. But still there are some that you should remember, for instance CD3, CD4, CD8, IL-1, IL-2, IL-8, IFNs, TGFs, TNFs, etc. because IMO they are basic to understand the mechanism.

As a marker, CD# is specific for generating a cognate interaction (cell to cell interaction). Well, simply it works like receptor:ligand, one receptor is specific for one ligand. For example:
- T-cells that bring CD4 on their membrane, they are called as CD4+ T cell, will recognize only cells that express MHC classII on their membrane
- CD28 will interact only with B7 (protein molecule of the macrophage)
etc.

Also it can be used to distinguish such lymphocyte from different clones. For example:
- all lymphocytes has CD3, so they are called as CD3+, except NK cells, they lack CD3 or CD3-, so by immunohistochemistry for CD3 staining, you can distinguish NK cells from another lymphocytes.
- CD2 only possesed by B cell, you can distinguish B cell from T cell.
etc.


It seems that you are interested in Immunology eh? Learn well, I support you, I need a good assistant for helping me in practical labwork ;)
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