Wound Healing

[Squawkbox]

does anyone know where i could find a flow diagram of wound healing phases or something which lists the order things happen, ive tried google but theres nothing very clear which mentions specific cells etc.

tvm squawkbox

[Dr.Stein]

Is this what you are looking for?

Cascade Reaction of Blood Clotting

[honee_v]

u always have nice pix doc

thats about the start of the healing process.. wen the extent (e.g. depth, loss of tissues) of the wound is considered the process could vary... a cut may heal by mere wound closure, but if chronic like an ulcer, or burn injury, by contraction and reepithelialization...


^_^

[honee_v]

most wounds would undergo 3 general phases: inflammatory, proliferative and tissue remodelling phases

starts with blood clotting --> sends out signals to call for polymorphonuclear cells... then comes the monocytes (for phagocytosis and release of growth factors)... these generally happen during inflammatory phase...

then the proliferative phase, which consists of about 3 processes: fibroblast proliferation (for collagen deposition and wound contraction) and epithelial proliferation (to generate new epithelial cells) and angiogenesis - basically to replace damaged or lost cells

lastly the tissue remodelling phase, which is remodelling (collagen degradation, resynthesis and maturation) and scar formation... all these are in general... healing process involves several mechanisms...


^_^

[honee_v]

if you like you can also view this:

http://www.residentnet.com/bsframe.htm

at the bottom u can choose levels: 'in brief' or 'in depth'

hope this also helps



^_^

[Dr.Stein]

As you see, I am not sure which one Squawkbox wants. Thus I provided the beginning of the process. You can see my question mark up there ^

[honee_v]

u always got nice pix to share... seems u also teach doc ei?

^_^

[sdekivit]

the book 'Pathologic Basis of Disease' by Cotran et al describes in 2 chapter the acute, chronic inflammation and the following angiogenesis en tissue healing and remodelling.

[Dr.Stein]

u always got nice pix to share... seems u also teach doc ei?

^_^

Yes, I am a teacher. I should provide nice pics and slides to make my students happy in the class

[sdekivit]

or impress them with complicated signal transduction cascades

[honee_v]

or impress them with complicated signal transduction cascades

so not

sumtimes visuals are better than plain talk.. esp in science... & sumtimes visuals speak more


^_^

[Dr.Stein]

or impress them with complicated signal transduction cascades

You mean ITIM/ITAM? Whoa I love that! Also apoptosis mechanism with Fas ligand but not my students They think they are full enough with Complement Pathways I have no idea why, but Complement Pathways are "funny". I have a nice animation for it, unfortunately it came late after the class was over So nect semester!