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what is integrin????

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what is integrin????

Postby phoebe3p » Thu Oct 19, 2006 4:00 am

hello, does anyone here could help me with this.... what is integrin.......................................and if anyone know spanish pleaz let me know!!!!!!!!!..........im from peru!!!.....and it would so good to me to talk to someone who can explain me things in my native language!!!

Pleaz Answer me!..
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Postby Dr.Stein » Thu Oct 19, 2006 6:17 am

Integrins are heterodimeric cell-surface proteins involved in cell-cell and cell-matrix interactiions. They are important in adhesive interactions between lymphocytes and antigen-presenting cells and in lymphocytes and leucocytes migration into tissue. The beta-1-integrins, or very late antgens (VLA), are a family of integrins with shared beta-1 chains and different alpha chains that mediate adhesion to the other cells and to extracellular matrix proteins.

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thank you so much!!..ummm i got another question

Postby phoebe3p » Sat Oct 21, 2006 12:33 am

..what is kinetochore?...


Kinetochore attachment to spindle microtubule plus-ends
is necessary for accurate chromosome segregation during
cell division in all eukaryotes. The centromeric DNA of each
chromosome is linked to microtubule plus-ends by eight
structural-protein complexes1−9. Knowing the copy number
of each of these complexes at one kinetochore–microtubule
attachment site is necessary to understand the molecular
architecture of the complex, and to elucidate the mechanisms
underlying kinetochore function. We have counted, with
molecular accuracy, the number of structural protein complexes
in a single kinetochore−microtubule attachment using
quantitative fluorescence microscopy of GFP-tagged kinetochore
proteins in the budding yeast Saccharomyces cerevisiae. We
find that relative to the two Cse4p molecules in the centromeric
histone1, the copy number ranges from one or two for inner
kinetochore proteins such as Mif2p2, to 16 for the DAM–
DASH complex8,9 at the kinetochore–microtubule interface.
These counts allow us to visualize the overall arrangement
of a kinetochore–microtubule attachment. As most of the
budding yeast kinetochore proteins have homologues in higher
eukaryotes, including humans, this molecular arrangement is
likely to be replicated in more complex kinetochores that have
multiple microtubule attachments.


----> this is chinesse to me!...could you explain it in other words..
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Postby MrMistery » Sat Oct 21, 2006 7:57 am

kinetochore(as defined by Campbell 7th edition)
- a specialised region on the centromere that linkes each sister chromatid to the mitotic spindle.
i would add that the kinetocore is a protein structure, it is not part of the chromosome per se
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Postby Dr.Stein » Sun Oct 22, 2006 2:22 am

Why do they talk about kinetochore here? :shock: :roll: Probably they are lost 8) :lol:
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Postby Poison » Mon Oct 23, 2006 3:22 pm

probably too lazy to open a new topic, doc.

PS: actually that's better for mods. :lol:
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Postby Dr.Stein » Thu Oct 26, 2006 9:01 am

Yeah...better for mods NOW, but then you will have many twin posts and you got busy to handle it :lol: :P
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