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Build up of residual bodies...

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Build up of residual bodies...

Postby DMDhopefully » Wed Oct 18, 2006 2:43 am

Well I was learning a little bit about lysosomes in my Cell biology class and my textbook mentions that the build up of residual bodies that can not be removed from the cell is a contributing factor to cell aging especially in long lived cells (nerve cells, ect.). I was wondering what would theoretically occur if these long life cells were able to get rid of their residual bodies? Would there be a marked decrease in cell aging? What kind of problems might there be... excessive waste? intrinsic dangers of residual bodies? What kind of research is being done in this field? I have ideas, but not sure if there are any concrete answers out there. Thanks.


Chris

PS. This isnt a hw question or anything, I was just curious
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Postby DMDhopefully » Sun Oct 22, 2006 5:05 pm

Anyone have any info/ideas?
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Postby G-Do » Sun Oct 22, 2006 6:01 pm

Are you talking about protein aggregates? Specifically, amyloid bodies? The buildup of aggregated amyloid precursors in nervous tissue is highly correlated with the onset of Alzheimer's. Some researchers suspect that the presence of these bodies results in an increase in reactive oxygen species in the cell, which can contribute to DNA damage and senescence. If you want a review of this subject, I think your best bet is to go to PubMed and dig up a review from the Alzheimer's literature. Here is one that looks reasonable:

Glabe, Kayed. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology. 2006:66, ppS74-S78.

It's not free, so you'll have to get it through your local University library or an inter-library loan.

Hope that helps!
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Postby DMDhopefully » Sun Oct 22, 2006 11:26 pm

Thanks for the reply. I was talking about general lysosomal waste that builds up in the lysosomes over time and is never able to be released...but your specific example answers that question. Ill see if I can pull up that article. Thanks again.

Chris
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