deletion mutation

[hustla7]

can anybody please tell me a common disease which is the cause of a deletion mutation, one which is the cause of a substitution mutation and one which is caused by an insertion mutation? i'm having lots of problems doing my biology homework...

thanx in advance

[LilKim]

It took me about 3 mins to find examples of these types of mutations.

To make this a learning experience (for you too)...

Go to http://www.wikipedia.org and type in: Genetic disorder

Read through... check out the links in the text and you'll find it

... I know you can!
- KIM

[hustla7]

Thanks a lot LilKim. I tried for days tryna find the disorders organised in this way...thnx so much for this kimmy....helped a GREAT deal. Thank you for using your time in helping me!! Much appreciated.

[keef]

A genetic deletion is a genetic aberration in which part of a chromosome is missing. This causes several serious genetic diseases.

One example of genetic deletions is Cri du chat, also known as "cry of the cat" syndrome. It is found in approx. 1 in 50,000 live births. The surviving infants have a distinctive cry, severe mental retardation, and shortened life span.

Deletion is the loss of genetic material. Causes:

* losses from translocation
* crossovers within an inversion
* unequal crossing over
* Breaking without rejoining

Small deletions are less likely to be fatal; large deletions are usually fatal - but always, there is variation based on what genes are lost. Some medium-sized deletions lead to recognizable human disorders.

A gene deletion, or deletion mutation is a mutation in which a part of a chromosome or a sequence of DNA is missing. Any number of nucleotides can be deleted, from a single base to an entire piece of chromosome (Lewis, 2005, p.226). Deletions can be caused by errors in chromosomal crossover during meiosis.

Deletion of a number of base pairs that is not evenly divisible by three will lead to a frameshift mutation, causing all of the codons occurring after the deletion to be read incorrectly during translation, producing a severely altered and potentially nonfunctional protein.

[hustla7]

thnx a lot dude- great help!! Bio Online Rocks!

[keef]

no prob. happy studying