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Contact Dermatitis ( allergic)

Human Anatomy, Physiology, and Medicine. Anything human!

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Contact Dermatitis ( allergic)

Postby fireblaze » Mon Aug 07, 2006 8:17 pm

COntact Dermatitis is skin disorder. This may be due allergies such as in foodstuffs. A person with this disorder would produce more IgE - antibodies. when the allergen and its complementary IgE proteins meet and react. this reaction is called hypersensitivity.

the IgE and allergen react to release mediators, such as histamine. this causes the symptoms: itchy rach in other words inflammation.

please correct any errors. thnx

how do mediators help promote or create an over reaction?
fireblaze
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Postby London » Fri Aug 11, 2006 2:59 pm

Dear fireblaze,

I do not have an answer for you but I am sure glad you posted the question and I eagerly await an answer.

London
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Postby fireblaze » Sun Aug 13, 2006 7:22 pm

could a biologist please help me
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Postby weesper » Tue Aug 15, 2006 9:52 am

What happens is that a person first needs to be exposed and the body's immune system will produce antibodies to the foreign agent (let's say nickel cuz that's a common contact allergy) after the immune system has produced these antibodies on reexposure these antibodies may bind the antigen (in this case nickel but can be rubber and all sorts of things). The complex attaches to a mast cell IgE receptor which releases mediators such as histamin and bradykinin upon binding IgE loaded with antigen to its IgE receptor. This releases causes the itching etc and that's what's meant be an 'overreaction'. Hope this helps take care mxj
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