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i figured it out

Debate and discussion of any biological questions not pertaining to a particular topic.

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Postby victor » Fri Jul 21, 2006 4:38 am

fealah wrote:What about polar surfase - I think, it is possible if to use antistatic electrecity, but how to do this is probably easy question for victor


Pardon me?? :lol:

I think that the teacher just want his/her students can create some imaginable viruses by using virology discipline...:lol:
Hey, continuing my previous post...you can create a virus which attack Basophils or mast cells. By using certain receptors in those mast cells which is usually get affected by allergen, you can create the resemblance virus' antireceptor. Oh, you also have to create an antireceeptor in order to bind RBC glycoprotein (glycoprotein which determines someone blood type, so the virus is "riding" the RBC to the mast cells place :lol: )

So, the mechanism is like this, when a virus is released (via airborne), it will get in into the target's body (usually via respiratory) and riding some RBCs there. Then, when it gets to the mast cell, this virus will change its host into mast cell and starting various mechanisms to replicate and also activate its host (mast cell) to produce massive histamine, leucotrine, prostaglandine, etc to promote a great anaphylaxis syndrome like a sudden vasodilatation which affect in sudden drop in blood pressure so, there'll be a sudden heart attack....
the result, as you all can predict..a sudden heart attack followed by other anaphylaxis syndrome in certain minutes can be lethal for someone..

Ooh...I've create an image of my virus... :twisted: :lol:
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Postby Mjhavok » Fri Jul 21, 2006 4:41 am

Victor can I ask what you do? for a living I mean.
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Postby victor » Fri Jul 21, 2006 11:57 am

I'm a student....an undergraduate university student...:lol:
so, I'm still jobless till now.. :lol:
all I can do is asking money to my parents in Jakarta to make a living here in Yogyakarta.. :mrgreen:
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Postby Mjhavok » Sat Jul 22, 2006 12:27 am

Indonesia. Did u get troubled by the Tsunami. There was also another recent tsunami in that area wasn't there.


What is your degree in?
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Postby victor » Sat Jul 22, 2006 4:24 am

Um, I'm fine here and I'm starting my 2nd year as an undergraduate biology student here...:lol: maybe we can continue this off-topic chat in off-topic discussion.. I'll wait you in "wanna chat 'bout anything..bio or not.." post.

Ok, back to the topic..I wanna modify my previous post.. :mrgreen:
I think that, by using blood type as a specific antigent is not enough since if I create a virus which attack A type, it would also attack AB type...then O type will be immune to that virus.
Ok, I think I'll design the new one...the concept is still the same, virus which is lethal for its anaphylaxis cause.
Type: Airborne virus, enveloped, +sense RNA virus.
Virion : spherical
This virus have an antireceptor which is complementary with B-cell receptor. By hijacking B-cell. it makes B-cell secrete massive amount of IgE (IgE is responsible for anaphylaxis syndrome and other allergic syndromes which is secreted in a little amount in body but has a very effective effect).
This Fc from IgE will bind the mast cells receptors and when a tiny allergen gets in into the victim, it will bind with Fab (fragment of antigent binding) from IgE and triggers the influx of Ca2+ ion towards mast cells and this means, mediator releasing...the mediator is consist of histamine, IFN-γ, leukotrine, etc.. And, when histamine is released, it will affect in increases in vascular permeability and drops the blood pressur in a sudden. So, the victim will die because of heart fail.

I'll post another further characteristic of this virus...let me think again for more...:lol:[/b]
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Postby MrMistery » Sat Jul 22, 2006 1:00 pm

Ok, so what you have to do is kinda hard. Humans have 99.9% the same DNA. The part that is not the same makes up some parts of non-coding DNA refered to as SNIPS. These are differences only in one base pair that occur once in every 1000 nucleotides at average in the human genome. So, if you would want to infect that particular person, your virus should recognise his/hers unique combination of SNIPS. No idea how to do that though...
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Postby victor » Sat Jul 22, 2006 1:07 pm

Hmm...I can suggest that I should know my victim's medical record and for that specific site, I think that immune systems has a wide variation about this (since one of them is adapted immunity).. :lol:
Ok, let's make one.. :mrgreen:
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Postby mith » Sat Jul 22, 2006 6:34 pm

FOXDIE is a fictional virus from the video game Metal Gear Solid. It is a retrovirus genetically modified to attack a specific person or peoples by identifying their DNA.

FOXDIE works by first infecting the macrophages in the victim's body. It contains smart enzymes created through protein engineering that are programmed to respond to specific genetic patterns in the cells. Recognizing the target's DNA, they then respond to the DNA by becoming active. Using the macrophages they begin creating TNF epsilon which is a type of cytokine, a peptide which causes cells to die. The TNF epsilon is carried along the bloodstream to the heart and there they attach to the TNF receptors in the heart cells. The heart cells suffer a shock and undergo an extreme apoptosis; in other words, the heart cells commit suicide. This kills the carrier with what appears to be a heart attack.

http://en.wikipedia.org/wiki/FOXDIE
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Postby victor » Sun Jul 23, 2006 2:38 am

mithrilhack wrote:It contains smart enzymes created through protein engineering that are programmed to respond to specific genetic patterns in the cells.


I can think that the bolded words must be hard to be created.. :lol:
but, nothing impossible with this....because there's only one word that fit with "impossible" word, which is "mission", not "it's". :mrgreen:
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I'm the ANP teacher

Postby awyman » Tue Jul 25, 2006 12:35 am

Wow, I thought you guys were supposed to be thinking up this stuff on your own :wink:
anyway... the idea of the question was to get students to think about what kind of receptor is unique to a person's cells... and yes, I was going for MHCI, which is different on every person. If you could engineer the virus to recognize and bind to that, it could only infect that particular person. Yes, it would be nearly impossible to do, so I'm not too worried about getting arrested for suggesting it... I'm not crazy, honest! :)
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