Login

Join for Free!
114120 members


Viruses

About microscopic forms of life, including Bacteria, Archea, protozoans, algae and fungi. Topics relating to viruses, viroids and prions also belong here.

Moderator: BioTeam

Viruses

Postby student12 » Thu Jun 01, 2006 11:59 am

I have tow questions, regarding viruses.

In my text book they say that viruses are specific. But how are they specific? And how do they infect an individual?
student12
Death Adder
Death Adder
 
Posts: 57
Joined: Wed May 10, 2006 10:36 am

Postby victor » Fri Jun 02, 2006 2:53 am

Um, about the specific one, could you write the full sentencee of that?
I can think that virus is specific because of their anti-receptor which is only specific with its target cells.
There are certain types on how virus infect its target and the most common one is via endocytosis. this process can be done when the cell's receptor is fit with virus' anti-receptor. But you have to notice that when endocytosis, not the whole virion gets in...only certain parts which are getting inside the host cell.
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby chemistry_freako » Fri Jun 09, 2006 11:30 pm

It depends on what context they're talking about.
As Victor said - specificity of the receptors and ligands,
before the virus gets 'engulfed'.
化学は、最高です

Image
User avatar
chemistry_freako
Coral
Coral
 
Posts: 193
Joined: Wed Jun 08, 2005 3:31 pm
Location: Somewhere between those molecules


Postby raju » Sat Jun 17, 2006 11:53 am

hi virus capsule is an protein .out of a body they r crystals .so cant move on there own or enter any thing
the viruses have specific proteins on there body by which they try to intreact wit othere cells which have complimentary structure of it
its more like an anti body antigen inter5action
due to this all the proteins have specificity of infection for example
HIV has on it a group of protein known as g 4 proteins which interact with only cd4 protein on the wall of T-lympocytes in humans hence they can infect only humans
the organisms that survive r not the one which r strongest nor the one which r briliant THEY R THE ONE WHICH RESPOND TO CHANGES IN NATURE FIRST
raju
Garter
Garter
 
Posts: 30
Joined: Wed Nov 02, 2005 6:39 am
Location: india

Postby BioChemistrySoldier » Tue Jun 27, 2006 1:21 am

Hey im going to try something, I want someone to tell me if it is wrong or what i should looke out for. im going to creat a virus that instead of multiplying itself, but multiplys the cell it hangs on to.

This is usful because some people in the world dont have some cells or there genes are bad. (like sickle cell anemia)
so by multiplying the cell they need. COULD, it be possible to help them or by using it for another cause.

Im going to probably take samples of other viruses and parts from plants and animals first, to look at what im going to do to creat it and store it.

Im into biological viruses more the anything.
Dont stop til ya get enough.
BioChemistrySoldier
Garter
Garter
 
Posts: 17
Joined: Sun Apr 16, 2006 12:30 am
Location: england,manchester

Postby herb386 » Tue Jun 27, 2006 8:30 am

If you wanted to make a stable change to the cells you would need to use a virus that could integrate into the genome. This has already been done in some medical trials to replace faulty genes but I think some people ended up with leukemia so there's still some work to be done in targeting the insertion.

There are already viruses that increase the rate of cell division in order to increase their reproductive rate but these viruses tend to be associated with cancers because they alter the cells cell division control mechanisms.

If you could come up with a way of turning the viral gene expression on and off reliably, inserting it in a specific gene free area, preventing virus replication and infecting only the correct cells it might work.
herb386
Garter
Garter
 
Posts: 39
Joined: Wed Jun 14, 2006 11:23 am
Location: UK

Postby herb386 » Tue Jun 27, 2006 8:33 am

The other thing is that you would get an immune reaction to the virus which may just kill the cells it enters.

Also if the virus can't replicate you would need to introduce quite a lot to ensure some will get into the cells. The problem then is that you can't control which cells are infected.
herb386
Garter
Garter
 
Posts: 39
Joined: Wed Jun 14, 2006 11:23 am
Location: UK

Postby victor » Wed Jun 28, 2006 7:12 am

Some of those replicator viruses do exist naturally. They're classified into retrovirus family, and classifided again into oncovirinae genus. And yes, this virus family oftenly related with cancer (the crabs :lol: )
If you wanna create a virus which is like you said,
first, you have to control the rate of the cell's reproduction if the cell is introduced with the virus.
Then, you must calculate and control the rate of mutation due to the insertion of the viral genome.
After that, you have to modify the viral genetic substances in order to avoid the cell's immune response (like interferon (IFN) releasing, expressio of cell's surface antigens, etc.)
And the last but not least, you have to target the virus into some specific cell in ordr to reproduce that 'specific' daughter cells.

Well, happy experimenting...:mrgreen: :lol:
Q: Why are chemists great for solving problems?
A: They have all the solutions.
User avatar
victor
King Cobra
King Cobra
 
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..

Postby Mjhavok » Fri Jun 30, 2006 3:10 am

BioChemistrySoldier wrote:Hey im going to try something, I want someone to tell me if it is wrong or what i should looke out for. im going to creat a virus that instead of multiplying itself, but multiplys the cell it hangs on to.

This is usful because some people in the world dont have some cells or there genes are bad. (like sickle cell anemia)
so by multiplying the cell they need. COULD, it be possible to help them or by using it for another cause.

Im going to probably take samples of other viruses and parts from plants and animals first, to look at what im going to do to creat it and store it.

Im into biological viruses more the anything.


Is this the sci fi forum? How exactly are you going to do this?
Forgive him, for he believes that the customs of his tribe are the laws of nature!
User avatar
Mjhavok
Coral
Coral
 
Posts: 163
Joined: Thu Nov 25, 2004 6:54 pm

Postby mkwaje » Mon Jul 03, 2006 3:36 am

Mjhavok wrote:
BioChemistrySoldier wrote:Hey im going to try something, I want someone to tell me if it is wrong or what i should looke out for. im going to creat a virus that instead of multiplying itself, but multiplys the cell it hangs on to.

This is usful because some people in the world dont have some cells or there genes are bad. (like sickle cell anemia)
so by multiplying the cell they need. COULD, it be possible to help them or by using it for another cause.

Im going to probably take samples of other viruses and parts from plants and animals first, to look at what im going to do to creat it and store it.

Im into biological viruses more the anything.


Is this the sci fi forum? How exactly are you going to do this?


Mjhavok is right. This study might be useful, but it is both mentally and financially challenging. To illustrate, you have to select your virus of interest. You say getting it from plants and animals? I assume these viruses you are referring to codes for a harmful gene. Then you have to be able to monitor it, therefore, you have to have animal or plant cell lines so that you can infect it with the virus in order to see / replicate it. Remember, viruses do not multiply outside their host cells. Also, you should have an in-depth understanding of the various genes that control cellular replication. Messing around with those genes using a virus won't transform those target cells into powerhouse replicating machines. There might be a slim chance for it to succeed, chances of having a safe and stable one is even slimmer.

just my two cents.
User avatar
mkwaje
Coral
Coral
 
Posts: 146
Joined: Mon Jul 03, 2006 2:48 am
Location: Philippines

Postby Mjhavok » Wed Jul 05, 2006 10:05 pm

Also this would take alot of research and alot of time.
Forgive him, for he believes that the customs of his tribe are the laws of nature!
User avatar
Mjhavok
Coral
Coral
 
Posts: 163
Joined: Thu Nov 25, 2004 6:54 pm

Postby Sang » Sat Jul 15, 2006 8:18 am

First, would I ask some question too? I have a lesson says that there has a Virus with a big genom. I don't remember exactly its name but I think there is "Mimivirus". May I have Information about it?
Sang
Garter
Garter
 
Posts: 17
Joined: Wed Jul 12, 2006 2:01 pm

Next

Return to Microbiology

Who is online

Users browsing this forum: No registered users and 2 guests

cron