bio cwk help

[littleginge]

im in yr 12 doing bio coursework titled 'the effect of detergent on cell membrane permeability'

with most of this im fine i understand surfactants and all that, its the enzymes from bio detergent that are puzzling me. would the protease in bio detergent be able to affect the intrinsic/extrinsic proteins in the bi-layer? or would it be the phopholipids be affected by another enzyme? if its affected at all

this would be a great help

thanks