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Thiamine Pyrophosphate

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Thiamine Pyrophosphate

Postby bearhug » Mon Feb 06, 2006 7:44 pm

TPP is synthesized from thiamine by enzymatic transfer of a pyrophosphoryl group from ATP. It is a coenzyme for Thiamine (Vitamin B1) just to inform anyone who doesn't know what it is. I was wondering if anyone knew if the prefix -pyro is significant in the naming of this coenzyme. I noticed that the structure for TPP has two phosphate groups and was curious as to why it wasn't called diphosphate instead.

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Postby victor » Tue Feb 07, 2006 12:24 pm

maybe it states that the bonding of those two phosphate molecule contains a high enegy bonds which is like in ATP which is phosphate anhydride instead of phosphate ester..I think the bonds is represented with (~) instead of (-).
and when these high energy bonds is broken down, it will generate much energy and one of the form is heat..(analogous to pyro isn't it??:wink:)
Ex: OP4~PO4~PO4-Ribose-nitrogenous base
(this is it??)

PS: this is only my opinion..for further detailed explanation, ask the creator of that name or ask the chemist..and don't try this at home..:lol:
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