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bohr effect

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bohr effect

Postby 1380sara » Sun Apr 16, 2017 9:12 am

In the Bohr effect, protonation of the N-terminal amino groups of of hemoglobin's alpha chains is responsible for 30% of the 0.6 mol of H+ that combine with Hb upon the relaease of 1 mol of O2 at pH 7.4. Assuming that this group has a pKa 7.0 in oxyHb, what is its pKa in deoxyHb?
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Postby claudepa » Tue Apr 18, 2017 10:05 am

I do not know the Bohr effect but it seems that you have an equilibrium between HBO2 and H+ on one side and HBH+ and 02 on the other. There should be one pKa for this equilibrium.
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