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possible treatments

Human Anatomy, Physiology, and Medicine. Anything human!

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possible treatments

Postby bionewbie » Tue Jan 31, 2006 3:56 am

What are some treatments for sporotrichosis?
bionewbie
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Postby Dr.Stein » Tue Jan 31, 2006 6:11 am

Well, first I should know what sporptrichosis is :roll: :oops:

Ah I know it:
Sporotrichosis is a subacute or chronic infection caused by the soil fungus Sporothrix schenckii. The characteristic infection involves suppurating subcutaneous nodules that progress proximally along lymphatic channels (lymphocutaneous sporotrichosis). Rarely, a primary pulmonary infection (pulmonary sporotrichosis) occurs, or direct inoculation into tendons, bursae, or joints occurs. Osteoarticular sporotrichosis occurs from direct inoculation or hematogenous seeding. Rarely, a disseminated infection occurs with disseminated cutaneous lesions and involvement of multiple visceral organs; this occurs most commonly in patients with acquired immunodeficiency syndrome (AIDS).

Infection with the dimorphic soil fungus S. schenckii usually is acquired through cutaneous inoculation. The initial reddish, necrotic, nodular papule of cutaneous sporotrichosis generally appears 1-10 weeks after a penetrating skin injury. The lesion is a suppurating granuloma that consists of histiocytes and giant cells, with neutrophils that accumulate in the center and that are surrounded by lymphocytes and plasma cells.

The fungus spreads from the initial lesion along lymphatic channels, forming the chain of indolent nodular and ulcerating lesions that typifies the lymphocutaneous form of the disease.

Other tissues are involved by direct extension and, less often, by hematogenous dissemination. The most common extracutaneous sites are in the bones, joints, tendon sheaths, and bursae. Hematogenous dissemination—particularly in immunocompromised hosts—results in widely disseminated cutaneous and visceral infection, including meningitis.

A rare form appears to result from inhalation of the organism. A chronic, cavitary pneumonia, which is clinically and radiographically indistinguishable from tuberculosis and histoplasmosis, occurs in patients who usually have severe underlying chronic obstructive pulmonary disease (COPD).

And I found this, maybe could help you ;)

Sporotrichosis Treatment

The skin infection is usually treated with potassium iodide (for example, SSKI) given by mouth 3 times per day or itraconazole by mouth. Treatment is prolonged and continues 1 month after the skin lesions clear. Systemic or disseminated infection is often treated with Amphotericin B, or sometimes itraconazole.

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