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glandular fever and antibiotics

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glandular fever and antibiotics

Postby maimutel » Thu Jan 12, 2006 6:26 pm

It's just for simple curiosity ...... we call that disease mononucleoza infectioasa ( infectious mononucleosis - I think the term might be similar in english as well ) . Anyway viral disease epstein barr type from herpesviridae familly ( I might be wrong about that one ) with no actual cure as it passes naturally and leaves the body with a life long immunity . A friend of mine has 2 kids and her son developed simptoms and went to doc where he was diagnosed although without blood sample to actually number the white cells present and put him on erythromycin ( eritromicina in romanian so scuze me if I spelled the name wrong ) . Now ..... my questions related to the subject are : Is erythromcine different in stucture than penicilin ? ( I know penicilin has an particular aromatic segment ) . And can someone give me a hint in why penicillin gives such a strong rection ( similar to a rash on the skin ) if it's taken when U have this particular disease ?
I know curiosity killed the cat but as long as knowledge doesn't give me headaches I think I'll take my chances .
Oh yeah almost forgot ..... ty in advance :)
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Postby Dr.Stein » Wed Jan 18, 2006 8:25 am

This is the structure of erythromycin (Streptomyces erythraeus)
Image

This is the structure of penicilin (Penicillium notatum)
Image

Can you see any difference? ;)

The strong reaction of penicillin (rash on skin) is one of several kinds allergic reaction against penicillin. This depends on individuals. Another side effects of penicillin are:
- Itching (pruritus)
- Diarrhoea
- Allergic reaction to active ingredient
- Fever (pyrexia)
- Inflammation of the large intestine (colitis)
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Postby canalon » Wed Jan 18, 2006 4:24 pm

Just to add my 2 cents erythromycine belongs to the macrolide family, which has no cross resistance to the beta lactam family to which penicillin belongs.
Erythromycine also stimulates non specific immunity and increase the number ofB and T lymphocyte. This is probably the reason why it was prescribed to your friends kid.
Patrick

Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
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Postby Dr.Stein » Thu Jan 19, 2006 5:30 am

Canalon wrote:Erythromycine also stimulates non specific immunity and increase the number of B and T lymphocyte. This is probably the reason why it was prescribed to your friends kid.

Hey, thanks for the info. This is a brand new info for me and I found I am interested on this :)I have an idea to include this topic for my Immunology labwork next semester :D Thanks again ;) Now I should start to culture Streptomyces erythraeus . Unfortunately I am not good in Microbiology. Any suggestion for me please? :? 8)
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