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Postby IneptStudent » Fri Jan 06, 2006 12:06 am

Hmmm... I use to be able to remeber this term but I can't quite remember what the temperature elevating protein released by WBCs is named...Anybody have any answers or guesses?
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Postby mith » Fri Jan 06, 2006 4:59 am

pyrogen?
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Postby 2810712 » Fri Jan 06, 2006 9:40 am

i think its pyrogen.
by the way if mods permit, in the same thread, i want to know how do pyrogens help us...
is it like- stimulus[=?]----->WBCs----->pyrogens------>higher temp.--
-----> more K.E. ...high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]------>higher chances killing or blocking certain pathogen.

If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.

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Postby IneptStudent » Fri Jan 06, 2006 10:03 pm

alright... thank you very much
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Postby Dr.Stein » Sat Jan 07, 2006 8:03 am

So, it seems that I came very late :P Well, no question anymore? Problem is solved, case is closed :)
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Postby 2810712 » Sat Jan 07, 2006 9:32 am

Hey Dr. please help me too... or should i start a new thread in the hope that somebody replies...

Thanks.



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Postby Dr.Stein » Sat Jan 07, 2006 9:41 am

Of course I will help you if I could, but what's your question now?

Naaaah, don't open a new thread except you have a new topic please. If your question is still in this topic, fevers, then let's discuss just in here :)
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Postby victor » Sat Jan 07, 2006 1:20 pm

Pyrogens? not IL-2.... :?
antigens - APCs (granulocytes and macrophages) - Th1 - IL-2 - increasing hypothalamus thermostate - B-cell proliferation and plasma cell differentiation - activated Tc....
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Postby 2810712 » Sun Jan 08, 2006 4:12 am

I've explained my q -

i want to know how do pyrogens help us...
is it like- stimulus[=?]----->WBCs----->pyrogens------>higher temp.--
-----> more K.E. ...high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]------>higher chances killing or blocking certain pathogen.

If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.


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Postby victor » Sun Jan 08, 2006 12:45 pm

hey, wanna ask...is Interleukin-2 one of the pyrogen member??
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Postby Dr.Stein » Mon Jan 09, 2006 8:48 am

IL-2 is a cytokine, a T-cell growth factor.

Some examples of pyrogen are IL-1-alpha, IL-1-beta, IL-6, TNF family; all are cytokines produced by macrophage.
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Postby victor » Tue Jan 10, 2006 12:44 pm

But IL-2 is secreted by macrophage to affect hipothalamus and increase the body's temperature isn't it?
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