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what happen to the rest??

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what happen to the rest??

Postby victor » Mon Dec 26, 2005 1:29 pm

As a orangejuice lover sometimes I ask myself...if we consider that citric acid is the majority substances compared to ascorbic acid (maybe that's the reality) and in 1 day, I drink many glasses of orangejuice...is this will happen?
1. citric acid will directly undergo Krebs cycle without get combined with Oxaloacetic acid.
2. we excesses of Oxaloacetic acid because it's not used and get stuck from time to time.
3. some citric acid will be re-formed and combine with amine substances to form amino acid.
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Postby alextemplet » Mon Dec 26, 2005 6:44 pm

Wow, I love orange juice, but I never really thought about what would happen with all that acid. It'd be nice to find out, though.

:D OJ 4 life! :D
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Postby Poison » Tue Dec 27, 2005 7:07 am

I don't think the first will happen.
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Postby victor » Tue Dec 27, 2005 11:39 am

Poison wrote:I don't think the first will happen.


for the first, I doubt about it also because Krebs cycle is located in the matrix of mitochondria..any logical explainations??
I don't think that my research for orange juice will be sponsored by my faculty... :lol:
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Postby cookie » Tue Dec 27, 2005 2:43 pm

1. citric acid will directly undergo Krebs cycle without get combined with Oxaloacetic acid.

I dont' really agree with this ~
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Postby MrMistery » Tue Dec 27, 2005 9:16 pm

Well, he stated it as a hypothesis. So if you think it is wrong, come with some proof. I also find in unlikely to happen because that will mean it would lead to an increase in the number of molecules inside the mitocondria
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citric acid

Postby Jumpshooter » Wed Dec 28, 2005 6:56 pm

*all the extra citric acid will simply become a part of the Interstitial fluid and be urniated out. There will be no "net increase" in Krebs cycle intermediates.
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Postby victor » Thu Dec 29, 2005 11:58 am

I've think out a new hypothesis..just call it as my number 4. It stated like this:
Citric acid (6C) will undergo some modification and changed into PGAL and the rest is the same like glucose breakdown..

[quote="Jumpshooter"]*all the extra citric acid will simply become a part of the Interstitial fluid and be urniated out. There will be no "net increase" in Krebs cycle intermediates.[/quote="Jumpshooter"]
Let me explain the condition...just imagine you stop consuming glucose (means now your body will need energy from breakdown of carbon chains.). In order to fill the energy you need, you change the consumption of glucose become citric acid from orange juice (I know there must be some glucose also, but majority is citric acid).
the condition is like this: glucose will undergo it's own way (glycolysis-Krebs-ETC). But how about citric acid? (because majority is citric acid and you must've got energy from the breakdown of citric acid)
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Postby victor » Wed Jan 04, 2006 2:15 pm

Hey...OJ lovers in this forum....anyone wanna help me with this problem??
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Postby alextemplet » Fri Jan 06, 2006 2:27 am

Does that require drinking a bunch of OJ? If that's the case, then I'm in! 8)
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Postby MrMistery » Fri Jan 06, 2006 9:16 pm

ok, victor, here is my 2 cents
1. orange juice is just about 4% citric acid, so it won't help you very much...
2. have a closer look at how the krebs cycle works. citric acid needs CoASH in order to turn from alpha-ketoglutarate into succynil-CoA. So if there has been no turning of oxaloacetate into citrate from using acetil-CoA the Krebs cycle will be blocked.
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Postby victor » Sat Jan 07, 2006 12:45 pm

After joining with oxaloacetate via CoA-SH and citrate synthase, it will form citric acid and releasing the bound with CoA-SH.
Then, it will form alpha-ketoglutarate via dehydrogenase enzyme and after that it will form Succynil CoA via CoA-SH.
From here, we can see that the forming of citrate has no relation with the forming of succynil CoA in the using of CoA-SH agent. So, if I put citrate directly without via oxaloacetate, what woul happen?
hmm...I wonder if we drink 75% citrate liquid....:wink:
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