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Protein synthesis during S phase

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Protein synthesis during S phase

Postby yuriw » Wed Sep 25, 2013 3:03 am

Hi,
Why does protein synthesis no occur during the S phase? i.e., why is there no transcription during replication (I'm assuming transcription, not translation, is stopped).
i've been looking everywhere for this answer, and I'm starting to think it's something ridiculously obvious. Thanks for your help!
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Postby JackBean » Wed Sep 25, 2013 11:10 am

Are you sure there is no protein synthesis during S phase? If it is so, I'd say it's because the DNA is busy with all the replication and thus cannot lose time with transcription.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Postby yuriw » Wed Sep 25, 2013 4:14 pm

As far as I remember being told, only histone synthesis is active during replication. I was guessing the inactivation of all other protein synthesis had something to do with CDK/cyclin levels, some phosphorylation, or something to do with steric impedement at the origin of replication.
Still, that doesn't explain the histone part...
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Postby JackBean » Fri Sep 27, 2013 10:08 am

Why not? Expression of histone genes is for sure controlled differently than the other proteins since they are required during specific phase of the cell cycle when most other proteins are not required.
http://www.biolib.cz/en/main/

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