Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.
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hi there i have been given this title to do a powerpoint presentation on!!!
The molecular substrate for electrical synapses in mammalian central nervous system:connexins, pannexins or both?
i am really strugglin with understanding the topic and finding some information to break it down in simpler terms for me!??
can anyone help me at all, as it has to be done by thurs 3rd
If you are ready for something really complete, but probably tough, try this (it's free):
Otherwise Entrez http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=PubMed
has a lot of information (try to search the books database (though I haven't found anything on pannexins) and is always a good starting point.
Sorry, I can't help. In PubMed I found only 6 references to pannexins, and none in the books. If you can acces to the review by Connors & Long, a cursosry reading of the abstract seem to show that it could probably be answering somme of your questions.
And I am a microbiologist, and not particularly knowledgeable about cell structures.
One of the 6 references found in PubMed on pannexins. But you need access to Annual reviews in Neuroscience to go beyond the abstract. I don't.
In this review, we briefly summarize what is known about the properties of the three families of gap junction proteins, connexins, innexins and pannexins, emphasizing their importance as intercellular channels that provide ionic and metabolic coupling and as non-junctional channels that can function as a paracrine signaling pathway. We discuss that two distinct groups of proteins form gap junctions in deuterostomes (connexins) and protostomes (innexins), and that channels formed of the deuterostome homologues of innexins (pannexins) differ from connexin channels in terms of important structural features and activation properties. These differences indicate that the two families of gap junction proteins serve distinct, complementary functions in deuterostomes. In several tissues, including the CNS, both connexins and pannexins are involved in intercellular communication, but have different roles. Connexins mainly contribute by forming the intercellular gap junction channels, which provide for junctional coupling and define the communication compartments in the CNS. We also provide new data supporting the concept that pannexins form the non-junctional channels that play paracrine roles by releasing ATP and, thus, modulating the range of the intercellular Ca2+-wave transmission between astrocytes in culture.
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