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mutation-selection balanceModerator: BioTeam
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mutation-selection balanceI'm having problems figuring out the logic behind two formulas related to the Hardy-Weinberg equation. Here are two relevant excerpts from my textbook, Medical Gentics by Jorde, Carey and Bamshad:
N.B. √ is square root in case it's not visible. What I don't get is why are the formulas different. For a dominant lethal allele p = μ, but for a recessive lethal allele q = √μ. How did they arrive at the square root? It makes intuitive sense because there will be a higher frequency for lethal recessive alleles than dominant lethal alleles. If you have a recessive disease, AA and Aa do not have the disease so the frequency of a is higher than in the case of a dominant disease where AA and Aa have the disease. But mathematically it doesn't make sense to me. Does anyone have any ideas? Thanks.
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