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B12 absorption/intrinsic factor

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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B12 absorption/intrinsic factor

Postby rk386 » Tue Aug 28, 2012 10:11 pm

How does the lining of the small intestine absorb the B12/intrinsic factor complex into the bloodstream? Does the B12 separate from the intrinsic factor or are the two absorbed as a unit?
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Postby rk386 » Wed Aug 29, 2012 6:35 pm

Basically, how does intrinsic factor work?
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Re: B12 absorption/intrinsic factor

Postby david23 » Sat Sep 08, 2012 3:57 pm

This is a pretty straightforward thing, you dont trust wikipedia? intrinsic factor has to bind to b12 for it to be endocytosed.

If you rephrase your question ask what is B12 deficiency like then I can help you there because that sounds more like the questions you are wondering.
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Re: B12 absorption/intrinsic factor

Postby rk386 » Mon Sep 10, 2012 5:31 pm

Once the B12/intrinsic factor complex gets endocytosed (by what kind of cells?) and into the blood stream, where does it go next? When does the complex get broken up?
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Re: B12 absorption/intrinsic factor

Postby david23 » Tue Sep 11, 2012 12:45 am

Oh since we are in the small intestine I have guess maybe enterocytes. The complexes are broken once it gets taken. From blood it goes to a lot of places, oh like your CNS first example.
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