Switch to full style
Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.
Post a reply

Enzymes

Mon Aug 06, 2012 3:36 pm

Do enzymes in the body last permanently, or do they over time get broken down and then replenished/rebuilt/replaced? Also, what controls the amount of enzyme present?

Re: Enzymes

Tue Aug 07, 2012 3:32 pm

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

This page might help the system make more sense.

http://en.wikipedia.org/wiki/Proteolysis

Re: Enzymes

Tue Aug 07, 2012 10:08 pm

what controls the enzyme levels? your genes, and hormonal regulations which again your genes

Tue Aug 07, 2012 10:16 pm

you seem to put everything under genes, but genes are controlled by many factors as well

Re: Enzymes

Wed Aug 08, 2012 6:17 pm

Thanks. Follow-up question:

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

Is it known which types of enzymes break down quickly and which are persistent?

Wed Aug 08, 2012 6:33 pm

Yes, there are soe well-known examples. For those you don't know about, you can make some predictions.

Re: Enzymes

Wed Aug 08, 2012 9:47 pm

Thanks. If I wanted to look more into this, where would I look?

Wed Aug 08, 2012 10:03 pm

The first choice should be Alberts' The Cell

Wed Aug 08, 2012 10:07 pm

Oh, great, I have that.

Re: Enzymes

Thu Aug 09, 2012 3:19 pm

Look for "protein turnover". Here's an introduction. http://en.wikipedia.org/wiki/Protein_turnover

Wed Aug 15, 2012 4:04 pm

Thanks. Have studies on protein turnover been done for specific proteins, or is it just known in general that that is what happens?

Wed Aug 15, 2012 4:50 pm

It has been done for many specific proteins. One good method is pulse-chase analysis. http://en.wikipedia.org/wiki/Pulse-chase_analysis
Post a reply