Genetics as it applies to evolution, molecular biology, and medical aspects.
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a particular sequence of aminoacids determines the structure of a protein.so ven reaxns occur in the cell,and protein changes conformation and involves changes in active groups.so does the aminoacid sequence ever change or is it conserved???
Ok, i am not imposing anything here, all i am doing in this post is asking nicely: please write whole words, people that are not native english speakers, that are beginners(like my bio teacher) will not understand...
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter
No. Check the prions for example. That is also why chaperones are here to help getting a correct folding for the protein.
Yes, if the modified amino acid is replaced by an other that will not interfere with the rest of the structure it may well not alter it.
Last edited by canalon on Fri Oct 07, 2005 5:37 pm, edited 1 time in total.
I am not suggesting it, I am clearly stating it.
And since the active conformation is not always the one that will be reached if folding happens spontaneously, that is why chaperones are involved into protein folding.
And Prions are another good example of proteins that have many conformations with different activities:
- "Normal" protein with its activity
- "Pathogenic" prion that lose its normal acivity for an autocatalytic activity fofolding the normal proteins in more Pathogenic one.
thanx but wait a sec.tell me where i go wrong.
1.polypeptide is mae from aminoacids
2.they attain the 3-dd form.fine.
here's what's puzzlin' me.the activ groups of the constituent amino acids r projected outwards,rite?will the chemical changes in these groups change the identity of the amino acids and the protein as well??
Let me give you some example:
If mutation occurs in one of the codon triplets and causing an insertion like this:
AUG-UUU-ACA-GCA-CAG = Met-Phe-Lys-Ala-His [before mutation]
AUG-UUU-ACA-ACG-CAG = Met-Phe-Lys-Thr-His
From this mutation, it's clear that there's a change in the chemical structure [amino-acid sequence] and it's indirectly made the chain conformation unusual or inactive...
Q: Why are chemists great for solving problems?
A: They have all the solutions.
10 posts • Page 1 of 1
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