Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.
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DNA is a very stable molecule. How it is stored plays a big role in how long it will last. DNA that left inside and dry at room temperature can last for years, such as that found on hairs in a hair brush. DNA in harsh conditions such as high heat or strong chemicals, can degrade very quickly (minutes to years). DNA that is preserved well can last a very long time - an ancient human from over 4000 years ago was recently discovered with DNA of sufficient quality that it could be sequenced. DNA can stick around forever, as long as it is in the right conditions.
DNA get damaged or repaired.
The DNA damages proposes that aging is a consequence of unrepaired DNA damage accumulation. Damage in this context is a DNA alteration that has an abnormal structure. Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell dysfunction.
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages.
no mistakes are allow in medical life.
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