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Penicillin Allergies

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Penicillin Allergies

Postby Edher » Mon Feb 14, 2005 1:46 am

Saludos,

How are some people allergic to penicillin?

My hypothesis (humurous)

Some individuals have in common some enzymes with bacteria. (Let's call it Enzyme A) These are the same enzymes that bacteria use to build its cell wall. By consuming penicillin, competitive enzyme inhibitors block the active site of the enzymes A, thus impeding bacteria to form cell walls leaving them more vulnerable. However, this has a similar effect in other cells of the body of these subjects.

Someone please correct me, before I spread this information like bateria.

Thank You,
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Postby RobJim » Mon Feb 14, 2005 10:38 am

Normally the reason people don't become allergic to drugs is that the drug molecule is too small for the body's adaptive immune system to respond to. However with penicillin and some other drugs, the small drug molecule can react with and bond with large protein molecules. When this happens, the combined drug-protein molecule can be detected by the adaptive immune system and the immune system responds to the presence of these foreign molecules just like it responds to bacteria and other foreign objects.

The drug molecule is known as a hapten. A hapten is a molecule that can bind to antibodies (because it's foreign) but is too small to elicit the immune response.

I don't know why some people become allergic and others do not. Genetics probably has something to do with it.
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Postby Raegan » Tue Feb 15, 2005 2:55 am

Penicillin belongs to a family of drugs called beta-lactam antibiotics. These drugs include penicillin and amoxicillin, which are relatively inexpensive and generally effective at eradicating many common bacterial infections. These include skin, ear, sinus and upper respiratory infections.

Taken orally or injected, penicillin works by stopping the growth of bacteria in your body. Several different varieties of penicillin exist, and each targets a different infection in a different part of your body. You may have heard of some of the other varieties of penicillin, including:

Amoxicillin
Ampicillin
Dicloxacillin
Nafcillin
Penicillin V
Penicillin G

You aren't born allergic to penicillin, but you can develop an allergy to the drug once you've been exposed to it. After that, re-exposure to penicillin or related antibiotics can trigger an allergic reaction.

Allergic reactions occur because your immune system responds to the drug as if it were a harmful substance instead of a helpful remedy. For reasons not fully understood, your body creates antibodies called immunoglobulin to attack the medication. In most cases of penicillin allergy, the type of immunoglobulin that causes the most problems is type E (IgE).

The majority of children who are allergic to penicillin will outgrow it. Some patients simply lose their sensitivity to penicillin over time. Or, a virus may have initially caused the reaction. In other cases, the reason may never be known, BWAHAHAHAHA
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Postby ParadoxAngel » Wed Apr 26, 2006 2:11 am

I was born allergic to penicillin. My dad has the allergy, too.
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Re: Penicillin Allergies

Postby kiekyon » Wed Apr 26, 2006 7:03 am

Edher wrote:

My hypothesis (humurous)

Some individuals have in common some enzymes with bacteria. (Let's call it Enzyme A) These are the same enzymes that bacteria use to build its cell wall. By consuming penicillin, competitive enzyme inhibitors block the active site of the enzymes A, thus impeding bacteria to form cell walls leaving them more vulnerable. However, this has a similar effect in other cells of the body of these subjects.

Someone please correct me, before I spread this information like bateria.



before u do that, antibiotics ideally are designed to attack a structure in the cellular machinery that bacteria have the humans do not. For instance, penicillin interrupts the building of the bacterial cell wall as u mention, however human do not have cell wall!
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