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## Help with Hardy-Weinberg Equation?

Genetics as it applies to evolution, molecular biology, and medical aspects.

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### Help with Hardy-Weinberg Equation?

If about 35% of the human population has type "O" blood,
a) What must the frequency of the type O allele?
b)what proportion of the populaton must be heterozygous carriers for type O?
lizziezelda
Garter

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Joined: Sun May 13, 2012 8:07 pm

Do you know, what does the HW equation looks like?
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

JackBean
Inland Taipan

Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

### Re: Help with Hardy-Weinberg Equation?

We are using the equation p2 + 2pq + q2 = 1, where
p2 = homozygous dominant frequency
2pq = heterozygous frequency
q2 = homozygous recessive frequency

You should know that blood type O is recessive. Therefore, q2 = .35. Taking the square root of .35 will give you the frequency of the type O allele (q):

sqrt (.35) = .592

Therefore, q = .592, and p = .408 (1 - .592)

In the Hardy-Weinberg equation, the frequency of heterozygotes is equal to 2pq. Therefore:
2 (.408) (.592) = .483

So, the proportion of the population that are heterozygous carriers is equal to .483 or 48.3%.

Sorry for the late reply! I am new to the site!
knorman
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Joined: Fri Jun 08, 2012 5:44 am