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caveolae and caveolin1

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caveolae and caveolin1

Postby marco86 » Sun Apr 29, 2012 2:02 pm

Hello,
I would like to ask you some questions about the caveolae and caveolin1
I didn't understand the paper that I read on that topic.

I would like to know what are the caveolaes? invagination of PM ? what are their function please? nutrients transport?
How, the caveolaes, are involved in diseases? How they are related to membrane tension?

And Caveolin1? it is a protein integral of PM, that is localizated on caveolae?

What is the mechanosensing and mechanotransduction??
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Postby taruntbiotech » Mon May 14, 2012 5:10 pm

1.caveolae which are a special type of lipid raft, are small (50–100 nanometer) invaginations of the plasma membrane in many vertebrate cell types, especially in endothelial cells and adipocytes.
have several functions in signal transduction.[1] They are also believed to play a role in endocytosis, oncogenesis, and the uptake of pathogenic bacteria and certain viruses.
2. Caveolins are a family of integral membrane proteins. involved in receptor-independent endocytosis.
Caveolin-1 has also been shown to play a role in the integrin signaling they have role in in the development of this disease like Muscular dystrophy and cancer
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