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Female XX genotype gives advantage for genetic disorders?

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Female XX genotype gives advantage for genetic disorders?

Postby SysBio » Fri Jan 27, 2012 9:03 pm

Hello,

I have read that since females have an XX genotype, they have an advantage over males' XY genotype for some genetic disorders.

If the female has a recessive allele on one X chromosome it may be covered by a dominant allele on the other X chromosome....but in males, any recessive allele on the X chromosome would be expressed.

But, I also read that in females, one of the X chromosomes becomes deactivated into a BARR BODY

How does a female have any genetic advantage if one of the X chromosomes becomes deactivated into a Barr Body?
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Postby JackBean » Tue Jan 31, 2012 3:54 pm

My guess would be because it is not deactivated uniquely and uniformly throughout the body
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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