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What is non-canonical polyubiquitination?

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What is non-canonical polyubiquitination?

Postby IRyanI » Sat Dec 31, 2011 1:55 am

I'm reading a research article and the sentence is, "TRAF2 is an E3 ligase that binds to Ubc13, resulting in non-canonical polyubiquitination of substrates involving lysine 63 rather than the canonical lysine 48 linking site."

What's it mean to be a non-canonical lysine and how does it differ in terms of structure and role from a canonical lysine? Am I even asking the right question here?

Thanks!
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Postby JackBean » Sat Dec 31, 2011 2:12 pm

I think that non-canonical here means something like non-standard or non-usual
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Postby JackBean » Sat Dec 31, 2011 2:13 pm

i.e. usually is the ubiquitin bound to K48, while in your case it is K63
http://www.biolib.cz/en/main/

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Postby IRyanI » Tue Jan 03, 2012 1:49 am

Sometimes the answer is more simple than you would assume. Thanks for the response JackBean.
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