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RNA decoy

Genetics as it applies to evolution, molecular biology, and medical aspects.

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RNA decoy

Postby Depo » Thu Dec 22, 2011 3:31 pm

I've recently heard about RNA decoy,but only little information.

If someone could explain me the biogenesis and its role I would be grateful :)
«Fanatical atheists are like slaves who still feel the weight of the chains from which they are released after a long struggle.They are creatures who,in their grudge against traditional religion,cannot hear the music of the spheres» A. Einstein
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Re: RNA decoy

Postby jonmoulton » Fri Dec 23, 2011 6:06 pm

RNA decoys are exogenous molecules that have a sequence matching the natural RNA target of an RNA binding protein. Usually the RNA binding protein binds to its natural target, but when the RNA decoy is introduced into the cell then it binds some of the RNA binding protein. If enough of the decoy is in the cell, the RNA binding protein is mostly attached to the decoy and some of its natural RNA target is left unbound. This essentially "flips a switch" in the cell, as the process affected by the RNA binding protein-RNA interaction goes from its bound state to its unbound state.

For example, if the RNA binding protein directs the splicosome to remove a particular exon, tying up that protein with an RNA decoy would cause production of a mature mRNA that contains the exon of interest (because the absence of bound RNA binding protein on its RNA target caused the splicosome to proceed differently with splicing).
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Re: RNA decoy

Postby Depo » Sat Dec 24, 2011 1:29 pm

Therefore the RNA decoy can bind to microRNA, allowing mature mRNA to start the protein synthesis
«Fanatical atheists are like slaves who still feel the weight of the chains from which they are released after a long struggle.They are creatures who,in their grudge against traditional religion,cannot hear the music of the spheres» A. Einstein
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