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Do the simplest bacteria have ribosomes and helicase?

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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Postby Daemach » Sat May 26, 2012 1:59 pm

1) I understand the DNA/RNA assembly process - I don't understand the phrase, "RNA composes of ATP besides others". (I read that as RNA is composed of ATP and other molecules)

2) Meh.

3) My definition of perfect sequence includes room for variability. If medicine wasn't at the state that it is today, cancer and genetic syndromes would kill a lot more people than it does today so they don't really fit the definition of "a cell that functions correctly".

Still, we're off topic again. My question is how we got to DNA in the first place. Frankly, I'm starting to lean towards Crick's opinion these days. Abiogenesis doesn't make much sense...
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Postby OdinsRaven » Sat May 26, 2012 6:13 pm

Don't forget where mitochondria came from. Before mitochondria merged with eukaryotes there may well, most likely, have been efficient mechanisms for producing/breaking down ATP.
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Postby dustman » Sat May 26, 2012 11:04 pm

Daemach, you must check chemical reactions in RNA synthesis before asking any more questions. Here's a link with a pic of actual nucleotide incorporation into oligo chain:
http://sandwalk.blogspot.com/2007/03/ho ... mical.html

Thing is, A, C, G and T/U in DNA/RNA molecule mean separate nuclotides, with purine/pyrimidine, carbohydrate and exactly one phospate group in-between. For synthesis of RNA ATP, CTP, GTP and UTP are used. As such, there is ATP among building blocks of an oligonucleotide. ATP, AMP, ADP and AAUUC are all RNAs, although first three more commonly called nucleotides, while RNA is generally refered to oligos. On another hand, DNA synthesis requires ATP but does not incorportate it into product, since it uses dATP as a building block.

Your idea of 'perfect DNA' smells of philosophical idealism. Redundant elements in organisms can be removed, but might be preserved as well. Perfect DNA wouldn't have excessive redundancy and variation, by defenition of 'perfection'. Something that is perfect under certain conditions might be a deadly flaw when these conditons change.
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Re: Do the simplest bacteria have ribosomes and helicase?

Postby jonmoulton » Fri Jun 01, 2012 3:10 pm

This is not directly addressing the questions in this discussion, but the topic is closely related and might be of interest.
http://blogs.nature.com/news/2012/06/dissolved-iron-may-have-been-key-to-rna-based-life.html#wpn-more-19146
I am including it here as an example of the ongoing research about the prebiotic world.
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