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Insulin - tissue rejection

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Insulin - tissue rejection

Postby Navin » Sat Sep 17, 2005 2:46 am

Is there a possible risk in tissue rejection if a person injects insulin inside his body which was obtained from animals?

What actually are the problems related to insulin obtained from animals that has led man to genetically engineer bacteria to produce insulin?
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Re: Insulin - tissue rejection

Postby canalon » Sat Sep 17, 2005 3:19 am

Navin wrote:Is there a possible risk in tissue rejection if a person injects insulin inside his body which was obtained from animals?

What actually are the problems related to insulin obtained from animals that has led man to genetically engineer bacteria to produce insulin?


It's cheaper and easier to produce. Before it was extracted from animals. This is expensive, poorly cost effective (How much insulin in a dead pig pancreas?) lead to safety concern (in case of virus contamination), and there maybe some slight differences between human and animal insulin. With bacterial insulin you can harvest insulin easily from a bioreactor, without safety concern and in huge quantities.
I guess the fact it sure doesn't come from pork could make some religious person happier too...

More here: http://www.littletree.com.au/dna.htm

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Postby victor » Sat Sep 17, 2005 12:08 pm

Maybe it's a little off topic but it's still related with insulin...ever heard diabetes type II? it's know as insulin-resistant diabetes where our bodies need more and more dosage of insulin to convert blood sugar..
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